Ancient DNA Confirms Malaria Claimed the Medici Brothers, Not Poison

A DNA study of Francesco I and Giovanni de’ Medici’s remains finds Plasmodium falciparum in both brothers and Plasmodium malariae in Francesco, confirming malaria—not poison—as the cause of death in 1587; researchers also identified a novel P. falciparum lineage in Giovanni, suggesting historic parasite movements across Europe during population growth. Published in iScience (2026) by Ochoa et al., the work aligns with Renaissance fever records and highlights how ancient DNA clarifies the history of one of humanity’s oldest diseases.