Alzheimer's drug fixes DNA damage and dampens brain inflammation in mice
TL;DR Summary
King's College London researchers report that KCL-286, a drug originally developed for spinal cord injury, repaired DNA double-strand breaks and reduced brain inflammation in a mouse model of Alzheimer's, attacking multiple early disease pathways beyond amyloid and tau. Since it has already cleared Phase 1 safety testing for another condition, it could move more quickly into Alzheimer's clinical testing.
Topics:health#alzheimers-disease#dna-damage-repair#health-and-medicine#inflammation#kcl-286#rarb-agonist
- New Alzheimer's drug repairs DNA damage and reduces brain inflammation ScienceDaily
- A Drug Already Proven Safe in Humans Just Reduced Multiple Signs of Alzheimer's in Mice ScienceAlert
- KCL-286 targets multiple Alzheimer’s pathways in preclinical study Drug Target Review
- New drug slows Alzheimer’s disease in mice Futurity
- This one drug may reverse brain damage in ways scientists never thought was possible! The Times of India
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