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Dna Damage Repair

All articles tagged with #dna damage repair

biology18 days ago•7 min saved

Immune Alarm Drives Rapid Aging: Blocking cGAS Reverses Tissue Damage

Researchers have linked an overactive immune sensor called cGAS to tissue degeneration in severe DNA repair disorders (like Ataxia-Telangiectasia and Bloom syndrome). Damaged DNA in cells can trigger cGAS, causing chronic inflammation that drives decline; reducing cGAS activity in a rapid-aging vertebrate model improved neuroinflammation, tissue function, and reproductive capacity. The work suggests aging-related decline may hinge as much on the body's inflammatory response as on unrepaired DNA damage, offering a potential new therapeutic angle with caution to preserve antiviral defense.

via SciTechDaily|

#aging #biology #cgas

science3 years ago•5 min saved

The Role of Metabolic Enzymes in DNA Damage Repair.

A new study published in Molecular Systems Biology has found that the human nucleus is metabolically active and can protect itself by appropriating mitochondrial machinery to carry out urgent repairs that threaten the genome's integrity. The findings represent a paradigm shift in cellular biology and can guide future lines of cancer research by offering new clues to overcome drug resistance and eventually the design of new treatments.

via News-Medical.Net|

#antioxidant-enzymes #cancer-research #cellular-metabolism

science3 years ago•2 min saved

The Impact of Microgravity on Human Cells in Space.

Scientists at Oklahoma State University have found that cellular repair systems respond to microgravity, which could help them better understand the effects of space flight on the human body. The researchers focused on SUMO, small proteins that attach to and modify other proteins in cells, and found that it plays a key role in cellular adaptation to microgravity stress. The study identified 37 proteins that physically interacted with SUMO, including those involved in DNA damage repair, energy and protein production, and maintaining cell shape and division.

via The Register|

#cellular-repair-systems #dna-damage-repair #microgravity