DT-109 Reverses Severe Fatty Liver Disease by Repairing the Gut Barrier

TL;DR
An experimental glycine-based tripeptide called DT-109 reversed severe metabolic dysfunction–associated steatohepatitis (MASH) in animal studies by strengthening the gut barrier and lowering intestinal ammonia, disrupting the harmful gut-to-liver inflammatory loop; findings in mice and nonhuman primates point to a new gut-targeted therapy approach for MASH, with clinical trials needed to assess safety and effectiveness in people.
Topics:healthhealth-and-medicine#dt-109#fatty-liver-disease#gut-barrier#gut-liver-axis#health-and-medicine#mash
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