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Fatty Liver Disease

All articles tagged with #fatty liver disease

Food-Systems Lens Links Western Diet and Binge Drinking to Rapid Fatty Liver Progression
health-and-medicine20 hours ago

Food-Systems Lens Links Western Diet and Binge Drinking to Rapid Fatty Liver Progression

A UVM PhD candidate physician studies how a Western-style diet with binge drinking accelerates fatty liver disease using a mouse model that mirrors human patterns; findings show rapid progression from fatty liver to inflammatory disease within about 12 weeks, especially in males, with no FDA-approved treatment—emphasizing prevention through food-system changes like greater access to minimally processed foods and reduced high-sugar products, while also exploring sex differences and dietary fat sources. The work underscores a systems-level approach to a medical problem and has earned the Graduate Research Excellence Award.

via The University of Vermont|
#alcohol#diet#fatty-liver-disease
Formoterol Reverses Fatty Liver Damage, Sparking Clinical Trials
health4 days ago

Formoterol Reverses Fatty Liver Damage, Sparking Clinical Trials

A decades-old asthma drug, formoterol, reversed fatty liver damage in mice modeling MASH and showed associations with fewer severe liver complications in people taking beta-2 agonists; MUSC researchers are moving to human trials to test whether the drug can treat MASH and diabetic kidney disease by boosting beta-2 signaling and mitochondrial biogenesis, though causal proof in humans is not yet established.

via SciTechDaily|
#beta-2-adrenergic-receptor#fatty-liver-disease#formoterol
Old Drugs, New Hope: Combo Reverses Fatty Liver in Animal Models
health-and-medicine1 month ago

Old Drugs, New Hope: Combo Reverses Fatty Liver in Animal Models

University of Barcelona researchers found that pairing two approved drugs, pemafibrate and telmisartan, reversed liver fat in MASLD animal models and may reduce cardiovascular risk; the duo was effective at half-doses together, suggesting synergy and safer therapy. Telmisartan appears to upregulate PCK1, shifting metabolism away from lipid synthesis. Human trials are still needed.

via ScienceDaily|
#drug-repurposing#fatty-liver-disease#health-and-medicine
Even 'Healthy' Drinks Can Damage Your Liver, Hepatologists Warn
health1 month ago

Even 'Healthy' Drinks Can Damage Your Liver, Hepatologists Warn

Hepatologists warn that the liver can be damaged not only by alcohol but also by everyday drinks—especially fruit juice—because MASLD (metabolic dysfunction-associated steatotic liver disease) can develop from metabolic syndrome. Excessive fruit juice can cause weight gain and insulin resistance, leading to fat buildup in the liver; fiber and whole fruit help protect the liver. Limit fruit juice, read sugar content, and consult a clinician or dietitian to tailor intake.

via AOL.com|
#dietary-fiber#fatty-liver-disease#fruit-juice
Eliminating senescent macrophages reverses fatty liver in mice
science1 month ago

Eliminating senescent macrophages reverses fatty liver in mice

UCLA researchers identify a population of p21+ TREM2+ senescent macrophages that drive liver inflammation and fatty liver; removing them in mice on a fatty/high-cholesterol diet reverses liver damage and inflammation without changing diet, using the senolytic drug ABT-263. However, ABT-263 is too toxic for humans, so researchers are seeking safer therapies, and human liver data show higher senescent macrophage signatures in diseased livers, suggesting potential relevance to people and other aging-related diseases.

via SciTechDaily|
#aging#fatty-liver-disease#p21
Hidden Liver Red Flags: 6 Common Symptoms and Subtle Clues to Watch For
health1 month ago

Hidden Liver Red Flags: 6 Common Symptoms and Subtle Clues to Watch For

Liver disease often goes undetected until a doctor diagnoses it, since it covers conditions from alcohol-related liver disease to MASLD/fatty liver, viral hepatitis, autoimmune, and genetic diseases. Common symptoms include fatigue, yellowing of the skin or eyes (jaundice), abdominal swelling, nausea, itching, and easy bruising. Subtle red flags like brain fog, trouble sleeping, joint pain, and on‑and‑off fatigue can also signal liver trouble. Risk rises with age, as liver function can decline in older adults. Protect your liver with a Mediterranean-style, low-sugar diet, regular exercise (about 150 minutes per week), and reduced alcohol intake, and consult a doctor if concerning symptoms appear, since early detection makes a difference.

via AOL.com|
#fatigue#fatty-liver-disease#health
Mounjaro reverses liver fibrosis in fatty liver disease, doctors report
health3 months ago

Mounjaro reverses liver fibrosis in fatty liver disease, doctors report

Two women with advanced fatty liver disease and fibrosis reportedly saw reversal of liver damage after using Mounjaro, a GLP-1 weight-loss drug. The case adds to growing evidence that treating obesity-related liver disease can reverse scar tissue, but NHS approval is still pending and access remains costly, underscoring the need for more research.

via dailymail.co.uk|
#fatty-liver-disease#glp-1#health
Long-term ketogenic diet linked to liver and sugar problems in mice
health-and-medicine4 months ago

Long-term ketogenic diet linked to liver and sugar problems in mice

In a nine-month-plus mouse study, a ketogenic diet prevented weight gain but caused fatty liver, dyslipidemia, and impaired insulin secretion, leading to poor blood-sugar control after carbohydrate reintroduction; effects were more severe in male mice, though some metabolic damage appeared reversible after stopping keto.

via ScienceDaily|
#fatty-liver-disease#glucose-intolerance#health-and-medicine
Majority of Indian IT workers suffer from fatty liver, unaffected by calorie cuts
health5 months ago

Majority of Indian IT workers suffer from fatty liver, unaffected by calorie cuts

A high prevalence of fatty liver disease (84%) among Indian IT employees is linked to insulin resistance, high carbohydrate intake, and genetic factors, with sugar consumption—especially fructose—playing a key role in liver fat accumulation and inflammation, which can lead to serious liver and cardiovascular complications. Simply cutting calories or fat isn't enough; addressing insulin resistance and dietary habits is crucial.

via ThePrint|
#fatty-liver-disease#fructose#health