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Mash

All articles tagged with #mash

DT-109 Reverses Severe Fatty Liver Disease by Repairing the Gut Barrier
health-and-medicine3 days ago

DT-109 Reverses Severe Fatty Liver Disease by Repairing the Gut Barrier

An experimental glycine-based tripeptide called DT-109 reversed severe metabolic dysfunction–associated steatohepatitis (MASH) in animal studies by strengthening the gut barrier and lowering intestinal ammonia, disrupting the harmful gut-to-liver inflammatory loop; findings in mice and nonhuman primates point to a new gut-targeted therapy approach for MASH, with clinical trials needed to assess safety and effectiveness in people.

via ScienceDaily|
#dt-109#fatty-liver-disease#gut-barrier
Alan Alda Hates the Crying Moment That Redefined M*A*S*H
entertainment28 days ago

Alan Alda Hates the Crying Moment That Redefined M*A*S*H

Alan Alda reflects on the Season 1 moment from MASH in the episode Sometimes You Hear the Bullet, where Hawkeye loses a friend on the operating table and is comforted by Col. Henry Blake. He says he dislikes his crying performance in that shot, feeling he overacted, even as the scene is recognized as a turning point that fused tragedy with humor and helped push the series toward its dramatic legacy.

via TVLine|
#acting#alan-alda#entertainment
McLean Stevenson Departed M*A*S*H for Top Billing, Changing the Show's Arc
entertainment1 month ago

McLean Stevenson Departed M*A*S*H for Top Billing, Changing the Show's Arc

Stevenson quit M*A*S*H after three seasons, citing a desire for center-stage status and telling TV Guide he wanted to be “one of one” as Hawkeye became the series’ focal point. Co-creators Gelbart and Reynolds crafted Henry Blake’s death as a farewell that underscored war’s cold reality. Stevenson later regretted leaving, and his post‑M*A*S*H projects—The McLean Stevenson Show and Hello, Larry—failed to reach the show’s earlier success, cementing the exit as one of TV’s most infamous.

via TVLine|
#alan-alda#entertainment#henry-blake
Formoterol Reverses Fatty Liver Damage, Sparking Clinical Trials
health1 month ago

Formoterol Reverses Fatty Liver Damage, Sparking Clinical Trials

A decades-old asthma drug, formoterol, reversed fatty liver damage in mice modeling MASH and showed associations with fewer severe liver complications in people taking beta-2 agonists; MUSC researchers are moving to human trials to test whether the drug can treat MASH and diabetic kidney disease by boosting beta-2 signaling and mitochondrial biogenesis, though causal proof in humans is not yet established.

via SciTechDaily|
#beta-2-adrenergic-receptor#fatty-liver-disease#formoterol
Gwen Farrell Adair, M*A*S*H Nurse and Trailblazer, Dies at 94
obituaries2 months ago

Gwen Farrell Adair, M*A*S*H Nurse and Trailblazer, Dies at 94

Gwen Farrell Adair, the versatile actress who played multiple nurses on M*A*S*H, died of natural causes at age 94 in Sherman Oaks. Born in Austin, Texas, she appeared on M*A*S*H from its 1972 debut through its 1983 run, and also acted in Starsky & Hutch and films such as Black Gunn, Soylent Green, Coffy, Earthquake, Towering Inferno, and Billy Jack Goes to Washington. Beyond acting, she managed Los Angeles boxers, became the first female licensed referee in 1979, and owned a Fatburger franchise. Her family described her as a guiding light and scheduled GoFundMe arrangements for funeral expenses.

via Deadline|
#actress#boxing#gwen-farrell-adair
Vitamin B3 Shows Promise as a Safe, Cost-Effective Treatment for Fatty Liver Disease
health10 months ago

Vitamin B3 Shows Promise as a Safe, Cost-Effective Treatment for Fatty Liver Disease

Scientists at UC San Diego have developed an investigational drug, ION224, that targets the root cause of severe fatty liver disease (MASH) by inhibiting the enzyme DGAT2, showing promising results in a Phase IIb trial with significant liver health improvements and no serious side effects, offering hope for a potential new treatment to halt or reverse disease progression.

via SciTechDaily|
#clinical-trial#drug-development#fatty-liver-disease
Novo Nordisk's Wegovy Gains Momentum with Expanding Indications and FDA Approval
business10 months ago

Novo Nordisk's Wegovy Gains Momentum with Expanding Indications and FDA Approval

Novo Nordisk is expanding into the MASH treatment market following FDA approval of Wegovy for this condition, which could significantly increase the company's market opportunities. While Wegovy faces competition from Madrigal's Rezdiffra, the market's growth potential and the need for early diagnosis and treatment of MASH present substantial opportunities for both companies. The success of Wegovy and Rezdiffra will depend on market acceptance, payer coverage, and ongoing research, with the overall MASH drug market expected to reach over $15 billion by 2032.

via Investor's Business Daily|
#business#market-growth#mash
FDA Approves Wegovy for Liver Disease, Boosting Novo Nordisk Shares
health11 months ago

FDA Approves Wegovy for Liver Disease, Boosting Novo Nordisk Shares

The FDA has approved Wegovy, a weight loss drug, for treating metabolic dysfunction-associated steatohepatitis (MASH), a liver disease linked to obesity that can lead to serious complications. The approval follows promising clinical trial results showing significant improvement in liver health for patients taking the drug, which may work through weight loss and reducing inflammation.

via The New York Times|
#fda-approval#health#liver-disease
Novo Nordisk's Wegovy Gains U.S. Approval for MASH Treatment
health11 months ago

Novo Nordisk's Wegovy Gains U.S. Approval for MASH Treatment

Novo Nordisk's Wegovy has received accelerated FDA approval to treat metabolic dysfunction-associated steatohepatitis (MASH), making it the first GLP-1 treatment approved for this liver condition, leading to a 7.4% rise in the company's shares. The approval is based on positive trial results showing significant improvement in liver fibrosis, and Wegovy's expanded use enhances its position in the metabolic disease market.

via CNBC|
#fda-approval#health#liver-disease