All articles tagged with #gut barrier
Researchers find tiny gut-derived exosomes may actively drive inflammation and aging-related diseases; exosomes from older animals induce metabolic and inflammatory changes in young mice, while exosomes from young animals alleviate several aging-related metabolic problems in older mice, highlighting the gut environment as a potential target for interventions.
Transferring gut microbes from young to aged mice rejuvenates the gut by reactivating intestinal stem cells, restoring crypt-villi structure and barrier function, and reducing inflammatory gene expression. The effects are mediated by microbial metabolites such as indole-3-aldehyde and butyrate, with Akkermansia muciniphila enrichment linked to the benefits.
A study reveals that sucralose, a common artificial sweetener, can produce a compound called sucralose-6-acetate in the body, which damages DNA and weakens the gut barrier, raising concerns about its safety and potential health risks. The findings suggest a need for regulatory review and further human studies to assess long-term effects.