GDF15 protects the liver from inflammation without weight loss via brain-to-liver signaling

McMaster University researchers found that the weight-loss hormone GDF15 can dampen liver inflammation and slow fibrosis through a brain-to-liver signaling pathway that triggers glucocorticoid release, even without changes in food intake, body weight, or liver fat. This reveals a potential inflammation-focused approach to treating advanced fatty liver disease (MASH).