Tag

Gdf15

All articles tagged with #gdf15

science17 days ago•72 min saved

Gut-Targeted Complex I Blockade Reveals Metformin’s Glucose-Lowering Mechanism

A Nature Metabolism study shows metformin lowers glucose by acutely inhibiting mitochondrial complex I specifically in intestinal epithelium, reducing citrulline production and boosting GDF15, thereby reprogramming the gut into a glucose sink that takes up glucose and converts it to lactate; phenformin and berberine act via the same intestine-specific Complex I mechanism, and the effect depends on short-term bolus exposure rather than chronic dosing.

via Nature|

#citrulline #gdf15 #intestine

health1 month ago•8 min saved

Metformin Reimagined: A 100-Year-Old Drug Tackles Hyperemesis Gravidarum

A health feature follows researchers and patients exploring metformin, a diabetes drug, as a potential preventive treatment for hyperemesis gravidarum (HG) by modulating the nausea-related hormone GDF15. Early observational data suggest taking metformin before conception may significantly reduce HG risk, with clinical trials in the works. The drug’s affordability, safety history, and broad off-label use—ranging from fertility in PCOS to obesity and potential antiaging effects—have spurred widespread interest, though more rigorous research is needed. The piece also shares the lived experience of HG and a patient hopeful that metformin could improve future pregnancies.

via Women's Health|

#gdf15 #health #hyperemesis-gravidarum

health1 month ago•65 min saved

Genetic trigger for extreme pregnancy nausea identified in largest study to date

A multi-ancestry genome-wide study links hyperemesis gravidarum (extreme pregnancy nausea) most strongly to the GDF15 gene, with several additional genes involved in insulin signaling and appetite. The findings move away from hCG and estrogen as primary causes and suggest GDF15 as the main driver of HG across diverse populations, opening avenues for new therapies (including metformin-based trials to desensitize against GDF15). The condition currently has no FDA-approved treatments, and researchers hope these insights guide diagnosis, prevention, and targeted therapies.

via Live Science|

#gdf15 #genetics #health

science1 month ago•38 min saved

Genetic map of severe pregnancy nausea uncovers 10 risk loci across diverse populations

A multi-ancestry GWAS of hyperemesis gravidarum (10,974 cases, 461,461 controls) identifies ten loci, including four known (GDF15, IGFBP7, PGR, GFRAL) and six new ones (SLITRK1, SYN3, IGSF11, FSHB, TCF7L2, CDH9); functional analyses show GDF15 and TCF7L2 activity in extravillous trophoblasts with opposing maternal vs fetal effects for GDF15, while IGFBP7 and PGR act mainly via the maternal genome in spiral arteries; loci link to pregnancy weight gain, duration, birth weight and preeclampsia, with additional signals involving antisense IGFBP7-AS1 and ACP1. The study draws on data from 23andMe, MoBa, Estonian Biobank, Genes and Health and others, and provides data and code access for replication and further exploration of appetite, insulin signaling and brain plasticity pathways.

via Nature|

#gdf15 #genome-wide-association-study #hyperemesis-gravidarum

health2 years ago•2 min saved

"Hope for Morning Sickness: Scientists Identify Possible Cause"

Scientists from the University of Southern California and University of Cambridge have discovered that the hormone GDF15, produced in the placenta, is the cause of morning sickness during pregnancy. The severity of symptoms is determined by a mother's sensitivity to this hormone. The findings open up potential avenues for treatment, such as lowering GDF15 levels or pre-exposing individuals to the hormone before pregnancy. This research could provide hope for the 70 to 80% of pregnant people who experience morning sickness, including severe cases known as hyperemesis gravidarum.

via CBS News|

#gdf15 #health #hyperemesis-gravidarum

health2 years ago•2 min saved

Breakthrough Discovery: Potential Cure for Morning Sickness Unveiled

Scientists have identified that the hormone GDF15 is largely responsible for causing morning sickness in pregnant women. The hormone, produced by the fetus, leads to nausea and vomiting. This discovery could pave the way for more effective treatments for morning sickness, which can be severe and debilitating for some women, requiring hospitalization. Understanding the relationship between GDF15 sensitivity and the severity of symptoms may help researchers develop preventive measures or a cure for morning sickness.

via The Cut|

#gdf15 #health #hormones

health2 years ago•2 min saved

Breakthrough Discovery: Link Between GDF15 and Morning Sickness Unveiled

A study conducted by researchers from the University of Southern California and the University of Cambridge has found a link between the protein GDF15 and the risk of nausea and vomiting during pregnancy, known as hyperemesis gravidarum. The study, which analyzed genetic data from over 500,000 women, identified a genetic variant associated with higher levels of GDF15, which in turn increased the risk of experiencing severe nausea and vomiting during pregnancy. The findings could potentially lead to the development of new treatments for this condition.

via Nature.com|

#gdf15 #genetic-epidemiology #health

health2 years ago•3 min saved

"Breakthrough: Uncovering the Enigmatic Hormone Enhancing Insulin Efficiency"

Scientists have discovered that GDF15, a hormone known for suppressing appetite, also improves insulin sensitivity in rodents. This finding could potentially lead to new treatments for diabetes. GDF15 has been found to enhance insulin efficacy in mice and rats, allowing them to regulate blood sugar and absorb energy more effectively. However, further research is needed to understand the exact role of GDF15 in human health and its potential benefits for improving insulin sensitivity in humans.

via SciTechDaily|

#diabetes #gdf15 #health

science-and-research2 years ago•3 min saved

Unexpected Findings from Biomarker Study

A biomarker study published in Biogerontology has yielded surprising results. The study recruited 169 participants and tested various biomarkers associated with aging. The findings revealed that growth differentiation factor 15 (GDF15), a marker of stress and mitochondrial dysfunction, was significantly associated with age, with the highest levels found in the 35-50 age group. In contrast, telomerase, a commonly studied biomarker of aging, did not show significant differences between age groups. Other biomarkers such as NLRP3 and advanced glycation end-products (AGEs) showed varying associations with age. The study's findings challenge conventional knowledge and call for further investigation and replication by other research groups.

via Lifespan.io News|

#aging #biomarkers #gdf15

health2 years ago•2 min saved

"Discovery of Hormone Pathway Accelerates Calorie Burning, Say Scientists"

Scientists have discovered a hormone-signaling pathway involving growth differentiation factor 15 (GDF15) that may help speed up calorie burning and prevent the body from entering power-saving mode during dieting. In a study involving mice, GDF15 was found to increase energy expenditure in muscle by ramping up calcium futile cycling, potentially aiding in weight loss and long-term weight management. Further research is needed to understand the mechanisms in humans and explore the potential of using GDF15 in combination with existing drugs for appetite suppression. With obesity becoming a global concern, new strategies are needed to address weight-related health issues.

via ScienceAlert|

#adaptive-thermogenesis #gdf15 #health

health2 years ago•2 min saved

"Hormonal Pathway Unveiled: Boosting Calorie Burn for Effective Weight Loss"

Researchers at McMaster University have discovered that the hormone GDF15, previously known for reducing appetite, may also help with weight loss by maintaining metabolism during dieting. The study found that GDF15 can prevent the slowing down of metabolism that typically occurs during calorie restriction, leading to continued weight loss. This research opens up possibilities for developing weight loss therapies and understanding individual variations in dieting success. Further studies are needed to confirm these findings in humans and explore the potential of GDF15 in combination with appetite-suppressing drugs.

via SciTechDaily|

#dieting #gdf15 #health

medical-science-news2 years ago•2 min saved

Unlocking the Hormonal Pathway to Sustainable Weight Loss

Researchers at McMaster University have discovered that the hormone GDF15 has the potential to promote weight loss and maintain calorie burning during dieting. The hormone blocks the slowing of metabolism that occurs during calorie restriction by increasing energy burn in muscle. This finding opens up new possibilities for helping people maintain weight loss after dieting and developing combination therapies with GDF15 and appetite-suppressing drugs. Further research is needed to confirm these findings in humans and explore the impact of GDF15 on weight loss.

via News-Medical.Net|

#dieting #gdf15 #medical-science-news

health2 years ago•2 min saved

Uncovering Hormonal Pathways to Boost Calorie Burning and Promote Weight Loss

Researchers at McMaster University have discovered that the hormone GDF15 can promote weight loss by increasing calorie burning in muscle. The study found that GDF15 blocks the metabolic slowdown that occurs during dieting by enhancing energy expenditure in muscle through calcium futile cycling. This research opens up possibilities for developing therapies to help people maintain weight loss and potentially combine GDF15 with appetite-suppressing drugs. Further research is needed to confirm these findings in humans and explore the potential of GDF15 in aiding weight loss.

via Medical Xpress|

#calorie-burning #gdf15 #health