Hidden in the nucleus, a fat-burning protein rewrites obesity biology
TL;DR
Scientists found that hormone-sensitive lipase (HSL), long known for releasing fat, also operates inside the nucleus of fat cells to maintain healthy adipose tissue and regulate metabolic processes. Loss of this nuclear HSL leads to lipodystrophy rather than obesity, helping explain why fat quality matters and suggesting obesity therapies should aim to preserve fat‑cell function, not just reduce fat mass.
Topics:healthhealth-and-medicine#adipose-tissue#health-and-medicine#hsl#lipodystrophy#metabolism#obesity
- New obesity discovery rewrites decades of fat science ScienceDaily
- NYU Abu Dhabi study identifies key protein behind genetic form of obesity Daijiworld
- Fat-burning enzyme has a secret second job that may reshape obesity research Earth.com
- Scientists discover hidden fat cell mechanism that could reshape obesity treatment The Eastleigh Voice
- New NYU Abu Dhabi study reveals how DNA organization in cells drives obesity and metabolic health ZAWYA
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