
Hidden in the nucleus, a fat-burning protein rewrites obesity biology
Scientists found that hormone-sensitive lipase (HSL), long known for releasing fat, also operates inside the nucleus of fat cells to maintain healthy adipose tissue and regulate metabolic processes. Loss of this nuclear HSL leads to lipodystrophy rather than obesity, helping explain why fat quality matters and suggesting obesity therapies should aim to preserve fat‑cell function, not just reduce fat mass.

