TNBC’s heterogeneity mapped: four cancer archetypes and eight tissue ecotypes forecast chemo response
TL;DR
A large single‑cell and spatial transcriptomics study of pretreatment TNBC identifies four cancer-cell archetypes and eight ecotypes defined by cancer cells and the tumor microenvironment, reveals macrophage and interferon‑related programs linked to better neoadjuvant chemotherapy response, and provides cell-state– and gene-based classifiers (including a 13‑gene panel) to predict pathological complete response, offering new insight into TNBC heterogeneity and potential immune targets such as LAG3 and HAVCR2.
Topics:health#health#neoadjuvant-chemotherapy#single-cell-sequencing#spatial-transcriptomics#triple-negative-breast-cancer#tumor-microenvironment
- Ecotypes of triple-negative breast cancer in response to chemotherapy Nature
- A 13-gene panel may help predict response to chemotherapy in triple-negative breast cancer Medical Xpress
- TNBC Ecotypes Reveal Molecular Signatures Tied to Chemotherapy Response Inside Precision Medicine
- New insights reveal why some triple-negative breast cancers resist treatment The Institute of Cancer Research (ICR)
- New Study Sheds Light on Predicting Chemotherapy Response in Triple-Negative Breast Cancer Bioengineer.org
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