Melatonin May Help Ease Chronic Musculoskeletal Pain

A meta-analysis of 23 randomized trials including 2,028 patients with chronic musculoskeletal conditions found melatonin reduced pain intensity by about 9 points on a 100-point scale and improved sleep quality. Doses ranged 3–10 mg (commonly 3 mg) taken at bedtime, with safety similar to placebo and mostly mild side effects like nausea, dizziness, or headaches. The researchers caution melatonin should complement—not replace—standard treatments and advise discussing use with a doctor, especially when other meds or health conditions are involved.