
Melatonin Shows Modest Potential to Ease Chronic Muscle and Joint Pain
A meta-analysis of 23 clinical trials involving over 2,000 participants suggests melatonin may modestly reduce chronic muscle and joint pain and improve sleep. The average pain reduction was small (about 9 points on a 100-point scale), with results weaker for post-surgical pain. Doses ranged from 1–10 mg and no optimal dose was identified; longer use might help a bit more, but evidence is limited. Melatonin should be considered as an add-on to established therapies (physiotherapy, exercise, anti-inflammatories), not a replacement. Side effects are generally mild, but those with liver/kidney conditions or autoimmune issues should consult a clinician. More large, well-designed trials are needed to confirm who may benefit.


