AI Algorithm Enhances Stability and Potency of mRNA Vaccines.

Researchers have developed an algorithm called LinearDesign that optimizes both structural stability and codon usage in mRNA vaccines, improving their half-life, protein expression, and immunogenicity. The algorithm takes only 11 minutes for the SARS-CoV-2 Spike protein and can be used for other mRNA medicines encoding therapeutic proteins. This breakthrough could help overcome the critical limitation of mRNA instability and degradation, making mRNA vaccines more efficient and effective.