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APOE2 Lets Neurons Fight DNA Damage, Slowing Brain Aging

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Source: SciTechDaily
APOE2 Lets Neurons Fight DNA Damage, Slowing Brain Aging
Photo: SciTechDaily
TL;DR

Buck Institute researchers show that APOE2 helps neurons repair DNA and resist aging by reducing DNA damage and cellular senescence; studies in human iPSC-derived neurons and aged mice reveal APOE2–driven DNA repair activation and better nuclear integrity, offering a potential mechanism for APOE2's lower Alzheimer’s risk and longer lifespan and suggesting therapies that boost DNA repair for APOE4 carriers.

Topics:healthscience#alzheimers-disease#apoe2#brain-aging#cellular-senescence#dna-repair#science
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  1. This “Longevity Gene” May Protect the Brain From Aging and Dementia  SciTechDaily
  2. 'Longevity gene' may protect the brain from Alzheimer's by boosting DNA repair, study finds  Fox News
  3. This Gene Is Linked to Lower Alzheimer's Risk – And We May Finally Know Why  ScienceAlert
  4. Longevity-linked APOE2 gene variant helps neurons repair DNA and resist aging  Medical Xpress
  5. APOE2 helps neurons repair DNA and resist aging (IMAGE)  EurekAlert!

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