Blocking EP2 Receptor Rejuvenates Aging Mice by Restoring Immune Cleanup
TL;DR Summary
A Stanford-led mouse study links aging-related decline to reduced clearance of senescent neutrophils by tissue-resident macrophages (TRMs) due to heightened EP2 signaling. Blocking EP2 signaling in old mice restored youthful TRM function, tempered inflammation, and improved memory, frailty, muscle, and heart. Analysis of 71 proteins showed many shifts toward youthful levels and pointed to the liver as a major contributor. Reanalysis of human liver and heart data showed similar patterns, suggesting EP2-targeted therapies might help aging, though no approved drugs exist and translation to humans remains uncertain.
- Blocking a Single Immune Signal Made Old Mice Act Young Again ScienceAlert
- We Might Have Been Wrong About How the Immune System Ages Medscape
- How aging affects the immune system and vaccines WTNH.com
- One immune switch may help drive aging across the body ScienceDaily
- Found an aging "switch" that slows down wear and tear of the entire body Baku.ws
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