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Neutrophils

All articles tagged with #neutrophils

Immune Switch Could Slow Aging, Study Suggests
science29 days ago

Immune Switch Could Slow Aging, Study Suggests

A Science study links aging to tissue-resident macrophages that accumulate the EP2 receptor, which hampers clearance of senescent neutrophils and fuels chronic inflammation. In mice lacking EP2, many aging-related blood proteins stayed younger, with notable improvements tied to the liver, suggesting EP2 as a potential target to slow aging. However, targeting EP2 without disrupting prostaglandin E2’s other roles is challenging, so researchers stress the need for approaches that preserve other functions while slowing aging.

via Yahoo News Canada|
#aging#ep2-receptor#immune-system
Blocking EP2 Receptor Rejuvenates Aging Mice by Restoring Immune Cleanup
science1 month ago

Blocking EP2 Receptor Rejuvenates Aging Mice by Restoring Immune Cleanup

A Stanford-led mouse study links aging-related decline to reduced clearance of senescent neutrophils by tissue-resident macrophages (TRMs) due to heightened EP2 signaling. Blocking EP2 signaling in old mice restored youthful TRM function, tempered inflammation, and improved memory, frailty, muscle, and heart. Analysis of 71 proteins showed many shifts toward youthful levels and pointed to the liver as a major contributor. Reanalysis of human liver and heart data showed similar patterns, suggesting EP2-targeted therapies might help aging, though no approved drugs exist and translation to humans remains uncertain.

via ScienceAlert|
#aging#ep2-receptor#liver
Heatstroke’s aftershock: why cooling may not end the danger
health2 months ago

Heatstroke’s aftershock: why cooling may not end the danger

Europe’s deadly heatwave is driving many heatstroke cases, where core body temperature above 40°C can cause brain dysfunction and multi-organ damage. Yet deaths can occur hours or days after cooling because the body’s immune system goes into a runaway, sepsis-like inflammatory state driven by neutrophils that damages blood vessels and triggers blood clots, overwhelming organs even once temperature is normalized. The current approach—rapid cooling—saves lives but doesn’t halt this immune cascade, so researchers are exploring strategies to calm neutrophil activity, prevent microthrombosis, and protect the gut barrier. Risk factors include age extremes, heart disease, diabetes, obesity, dehydration, alcohol, and certain medications. Faster cooling plus immune-targeted therapies could improve outcomes in heatstroke patients.

via The Conversation|
#health#heatstroke#heatwave
Liver palmitate fuels metastasis by dampening neutrophil attack through laminin-511 palmitoylation
science2 months ago

Liver palmitate fuels metastasis by dampening neutrophil attack through laminin-511 palmitoylation

A Nature Metabolism study shows that the liver’s palmitate-rich environment promotes breast and colorectal cancer liver metastases by suppressing neutrophil antitumor activity. Cancer cells use the palmitoyltransferase DHHC17 to stabilize and secrete laminin-511; this laminin-511 exposure dampens neutrophil cytotoxicity and NETosis, facilitating tumor growth. Silencing DHHC17 in cancer cells reduces liver metastases when neutrophils are present; adding laminin-511 or blocking neutrophil degranulation reverses this effect. Diets high in fat/palmitate increase NETs in metastatic livers, linking fatty acid metabolism to immune evasion. The work combines mouse models and human tissue data, highlighting palmitoylation-driven modulation of neutrophils as a metastasis mechanism in the liver.

via Nature|
#dhhc17#laminin-511#liver-metastasis
One Sauna Session Briefly Boosts Immune Cells in Blood
health-and-medicine2 months ago

One Sauna Session Briefly Boosts Immune Cells in Blood

A 30-minute sauna session with a mid-way cold shower temporarily increases all circulating white blood cell types, including neutrophils and lymphocytes, peaking during heat exposure and returning to baseline about 30 minutes after the session ends. The rise likely reflects mobilization of immune cells from tissues—a mechanism similar to exercise that could enhance immune surveillance—though cytokine changes were small and long-term effects remain unknown. The study involved 51 adults and was published in Temperature, focusing on immediate, not lasting, immune responses.

via ScienceDaily|
#health-and-medicine#immune-system#lymphocytes
Peripheral Neutrophils Forge C4A Link to Schizophrenia
science4 months ago

Peripheral Neutrophils Forge C4A Link to Schizophrenia

Stanford researchers find neutrophils actively produce C4A, a key schizophrenia risk protein, and in patients these cells pump out more C4A while rapid activation (C4-ana) occurs in plasma. The work links a peripheral immune process to brain synaptic pruning linked to schizophrenia, suggesting blood-based diagnostics and therapies that target the periphery rather than the brain. Clozapine’s neutrophil-depleting effects highlight the need for safer, targeted treatments.

via Neuroscience News|
#c4a#complement-system#neutrophils
Tumor-Modulated Neutrophils Fuel Cancer Growth via CCL3
science8 months ago

Tumor-Modulated Neutrophils Fuel Cancer Growth via CCL3

University of Geneva researchers find that neutrophils recruited to tumors are reprogrammed to produce the chemokine CCL3, which promotes tumor growth. This shift helps explain why some cancers become more aggressive and points to CCL3 activity in neutrophils as a potential prognostic biomarker and therapeutic target. The team used genetic tools to selectively suppress CCL3 in neutrophils and reanalyzed multiple studies to confirm the link.

via SciTechDaily|
#biomarker#cancer-progression#ccl3
Chronic Stress Triggers Immune Cells in Brain, Leading to Depression
health1 year ago

Chronic Stress Triggers Immune Cells in Brain, Leading to Depression

A study shows that chronic stress causes immune cells called neutrophils to leave skull bone marrow and gather in the brain's membranes, contributing to depression symptoms. Blocking an immune pathway reduced these cells and improved mood in mice, suggesting new immune-targeted treatments for depression, especially for those unresponsive to current drugs.

via Neuroscience News|
#brain-inflammation#depression#health
Mitochondria: Beyond Powerhouses, They Fight Germs
science1 year ago

Mitochondria: Beyond Powerhouses, They Fight Germs

Scientists have discovered that mitochondria, traditionally known for energy production, also play a crucial role in immune defense by sensing bacterial lactate and triggering neutrophil extracellular traps (NETs) to trap and kill bacteria. Dysfunctional mitochondria may weaken immune responses, as seen in autoimmune diseases like lupus, highlighting their importance in balancing immune activity and infection defense.

via Live Science|
#bacterial-detection#immune-response#mitochondria
"The Link Between Chronic Stress and Cancer Spread"
health2 years ago

"The Link Between Chronic Stress and Cancer Spread"

A study by researchers at Cold Spring Harbor Laboratory has revealed that chronic stress can increase the spread of cancer by causing certain white blood cells called neutrophils to form sticky web-like structures, making body tissues more susceptible to metastasis. The team's experiments on mice showed a significant increase in metastatic lesions in stressed animals, which was attributed to stress hormones acting on neutrophils to form these structures. The findings suggest that reducing stress and developing drugs to prevent the formation of these structures could be important components of cancer treatment and prevention.

via Cold Spring Harbor Laboratory|
#cancer-metastasis#cancer-research#chronic-stress
"The Link Between Chronic Stress and Cancer Spread"
health2 years ago

"The Link Between Chronic Stress and Cancer Spread"

Chronic stress can lead to a significant increase in cancer metastasis by activating neutrophils to form web-like structures that promote cancer spread. This breakthrough suggests that targeting neutrophil extracellular traps (NETs) formation could be a viable strategy to prevent cancer metastasis, emphasizing the importance of stress management as an essential part of cancer treatment and prevention. The findings offer potential new treatment strategies and highlight the need for integrating stress reduction in cancer care.

via Neuroscience News|
#cancer#cancer-treatment#health