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Liver

All articles tagged with #liver

Blocking EP2 Receptor Rejuvenates Aging Mice by Restoring Immune Cleanup
science1 month ago

Blocking EP2 Receptor Rejuvenates Aging Mice by Restoring Immune Cleanup

A Stanford-led mouse study links aging-related decline to reduced clearance of senescent neutrophils by tissue-resident macrophages (TRMs) due to heightened EP2 signaling. Blocking EP2 signaling in old mice restored youthful TRM function, tempered inflammation, and improved memory, frailty, muscle, and heart. Analysis of 71 proteins showed many shifts toward youthful levels and pointed to the liver as a major contributor. Reanalysis of human liver and heart data showed similar patterns, suggesting EP2-targeted therapies might help aging, though no approved drugs exist and translation to humans remains uncertain.

via ScienceAlert|
#aging#ep2-receptor#liver
science1 month ago

Hidden Tomato Compound Could Help Protect the Liver

Tufts University researchers found that phytoene, a colorless compound in tomatoes, reduced fatty liver severity in mice fed a high-sugar diet, suggesting whole tomato products may protect the liver beyond lycopene. Phytoene appears to promote liver fat burning through metabolic pathways and may require conversion into smaller metabolites to be effective. Genetic differences in processing enzymes and sex-based differences in liver accumulation could influence its benefits. If future studies in humans confirm these findings, increasing phytoene-rich fruits and vegetables could be a dietary strategy to prevent or slow metabolic liver disease.

via SciTechDaily|
#health#liver#nutrition
Fructose and Cancer: The Research Is Complex, Not Causative
health1 month ago

Fructose and Cancer: The Research Is Complex, Not Causative

Preclinical studies indicate fructose may affect cancer progression through altered tumor metabolism and liver processing, potentially aiding spread in some contexts, but this does not prove that fructose causes cancer. Experts advise limiting added sugars and sugar-sweetened beverages while allowing natural fructose from fruits and vegetables as part of a nutritious diet.

via AOL.com|
#cancer#fructose#health
Liver-Based Quantum Compass May Guide Pigeons Home
science4 months ago

Liver-Based Quantum Compass May Guide Pigeons Home

German researchers provide evidence that iron-rich macrophages in pigeons' livers may possess superparamagnetism and act as a liver-based quantum compass to help navigation, particularly when the Sun is obscured; experiments using clodronate to wipe these immune cells disrupted homing on overcast days, while normal navigation returned under sunny conditions, implying a liver-to-brain signaling pathway.

via ScienceAlert|
#liver#macrophages#navigation
Pigeons rely on a liver-based compass to navigate cloudy skies
science4 months ago

Pigeons rely on a liver-based compass to navigate cloudy skies

Scientists trained 34 pigeons to navigate a 12‑mile route and found iron‑rich immune cells in the liver may act as an internal magnetic compass, helping them sense Earth's magnetic field when visual cues are blocked by clouds. Pigeons depleted of these cells got lost under overcast skies, while birds with normal iron stores completed the route; after the cells naturally repopulated, navigation improved again. The cells display superparamagnetism and may relay directional information to the brain via nerves from the liver. While some scientists praise the possible new mechanism of magnetic perception, others call for more direct evidence before drawing firm conclusions. The research team plans to further investigate how immune cells communicate with the nervous system and to track pigeons globally to learn more about their navigation skills.

via CNN|
#immune-cells#liver#magnetoreception
A SIRT6 boost reverses much of age-linked liver chromatin changes in old mice
science4 months ago

A SIRT6 boost reverses much of age-linked liver chromatin changes in old mice

Bar-Ilan researchers showed that increasing SIRT6 levels specifically in the liver of 24‑month‑old male mice reversed about 80% of age-related chromatin accessibility changes within one month, with downstream inflammatory and metabolic gene programs moving toward a youthful pattern. The intervention used a hepatocyte-targeted viral vector and yielded tissue- and mechanism-specific reversal, not a universal rejuvenation. While scientifically significant for chromatin dynamics and aging biology, translating this to humans would require substantial further work, safety testing, and validation; the broader implications for human longevity are modest and long-term, not an immediate anti-aging breakthrough.

via Space Daily|
#aging#chromatin#liver
Wrong-site splenectomy leaves Florida surgeon 'forever traumatized' as manslaughter case unfolds
health5 months ago

Wrong-site splenectomy leaves Florida surgeon 'forever traumatized' as manslaughter case unfolds

In an eight-hour deposition, Florida surgeon Thomas Shaknovsky described how, during a difficult August 2024 splenectomy, he accidentally removed William Bryan’s liver instead of the spleen, Bryan died from exsanguination, and Shaknovsky labeled the organ as a spleen afterward; he says he is “forever traumatized” by the outcome as he faces a manslaughter indictment and ongoing civil litigation. The hospital said he no longer practices at its facilities, and Shaknovsky has previously faced other malpractice allegations and license removals in multiple states. The case remains under civil and criminal scrutiny as details of the procedure continue to emerge.

via NBC News|
#deposition#health#liver
Live-donor atlas maps healthy liver zonation and early steatosis dynamics
science5 months ago

Live-donor atlas maps healthy liver zonation and early steatosis dynamics

Researchers built a high‑resolution spatial atlas of the healthy human liver from live donors, integrating Visium, MERFISH and single-nucleus RNA‑seq to map hepatocyte zonation along the porto–central axis and compare with adjacent diseased tissue. They validate distinct pericentral and periportal programs, reveal early steatosis signatures such as reduced nuclear-encoded mitochondrial genes with compensatory mitochondria-encoded transcripts, and extend analyses to other mammals. The atlas provides a healthy-liver baseline to advance biology and disease research.

via Nature|
#live-donors#liver#science
One Week Off Alcohol: The First Wins Your Body Feels
health6 months ago

One Week Off Alcohol: The First Wins Your Body Feels

Stopping alcohol triggers quick and longer-term health shifts: within days you sleep better and stay hydrated; after a week your immune system and hormones rebound; after a month you may notice clearer skin and some weight changes; several months in, brain health and digestion improve; after a year cancer risk declines and emotional well-being often improves. Expect possible short-term withdrawal symptoms (anxiety, cravings, rapid heartbeat, restlessness, sleep problems) as your body adjusts, and plan alternatives to drinking or taper off if you’re a heavy drinker.

via AOL.com|
#alcohol#health#liver
Single-cell proteomics maps human liver zonation and its fragility in diseased tissue
science7 months ago

Single-cell proteomics maps human liver zonation and its fragility in diseased tissue

Researchers used advanced scDVP to profile hundreds of hepatocytes from 18 people, building a high-resolution map of protein gradients along the liver's porto–central axis. They quantified ~2,500 proteins per cell, showed roughly half are zonated, and introduced gradient-based analysis to quantify zonation without binning. Cross-species comparison with mice revealed shared and human-specific zonation features; in tissues with disrupted architecture, zonation is broadly lost. The study delivers an open-access liver proteome resource and a framework applicable to spatial proteomics.

via Nature|
#liver#proteomics#science