Cats and Humans Share Cancer Clues, Shaping New Cross-Species Therapies

An international study sequenced DNA from 493 feline tumors across 13 cancer types, revealing many shared driver mutations with humans—most notably TP53, with FBXW7 alterations in feline mammary cancers—and identifying UV-signatures in cat skin cancers; the research argues cats are a more relevant cancer model than mice and has released the dataset to researchers to pursue mutation-targeted therapies under the One Health framework, potentially advancing treatments for both cats and people.