Tag

Oncology

All articles tagged with #oncology

Oncologist Questions Whether Labeling DCIS as Cancer Drives Over-Treatment
health1 day ago

Oncologist Questions Whether Labeling DCIS as Cancer Drives Over-Treatment

Ductal carcinoma in situ (DCIS), often labeled stage 0 breast cancer, involves abnormal cells confined to breast ducts without spreading. While traditionally treated with surgery, radiation, or hormonal therapy, experts are increasingly questioning whether the 'cancer' label leads to unnecessary interventions. Recent studies suggest DCIS does not always progress to invasive cancer, prompting a shift toward personalized treatment decisions based on individual risk tolerance rather than automatic aggressive therapy. Mammograms remain the primary detection tool, though screening recommendations currently target ages 40 to 74.

N.I.H. Launches Coordinated Push to Accelerate Personalized Cancer Vaccines
health4 days ago

N.I.H. Launches Coordinated Push to Accelerate Personalized Cancer Vaccines

The National Cancer Institute (N.C.I.) is initiating a major public-private partnership in December to fast-track the development of personalized cancer vaccines. Led by N.C.I. Director Dr. Anthony Letai, the initiative aims to replicate the speed of the Covid-19 vaccine rollout by coordinating efforts between the N.I.H., the Foundation for the N.I.H., biotech firms, and patient advocacy groups. The program will initially focus on pancreatic, liver, and colorectal cancers, as well as pediatric tumors, with the goal of reducing the timeline for FDA approval from 15 years to 7-10 years.

US Cancer Survival Rates Reach 71% as New Report Highlights Decades of Progress
health5 days ago

US Cancer Survival Rates Reach 71% as New Report Highlights Decades of Progress

A new report from the American Association for Cancer Research indicates that the five-year survival rate for cancer patients in the United States has risen to 71%, up from 49% in the late 1970s. Significant improvements have been seen in lung, liver, and childhood leukemia treatments, driven by advancements in surgery, immunotherapy, and refined dosing protocols. While progress is substantial, survival rates for certain malignancies remain low, highlighting ongoing challenges in oncology.

TA Repeats Expose a Structural Weakness in Cancer’s Extrachromosomal DNA
science-and-health6 days ago

TA Repeats Expose a Structural Weakness in Cancer’s Extrachromosomal DNA

Researchers at Memorial Sloan Kettering Cancer Center (MSK) have identified a built-in structural vulnerability in extrachromosomal DNA (ecDNA), a circular genetic material found in roughly one in six human cancers. The study, published in Nature, reveals that repetitive TA sequences in ecDNA are prone to breaking, forcing cancer cells to rely on specific repair proteins to maintain stability. Disrupting these repair mechanisms destabilizes the DNA circles, offering a potential new therapeutic avenue to combat treatment-resistant tumors.

Endpoints News Highlights 20 Women Driving Change in Biopharma

Endpoints News Highlights 20 Women Driving Change in Biopharma

Endpoints News has released its eighth annual special report recognizing 20 women who are significantly influencing the biopharmaceutical industry. The honorees span diverse sectors, including oncology and rare disease research. This initiative is part of a broader effort that has recognized over 160 women across various biopharma sectors since the program's inception.

Fierce Biotech Unveils 2026 Fierce 15: A Focus on Fertility, Oncology, and AI
biotechnology8 days ago

Fierce Biotech Unveils 2026 Fierce 15: A Focus on Fertility, Oncology, and AI

Fierce Biotech has released its 2026 Fierce 15 list, highlighting 15 private biotech companies selected for their innovative approaches to unmet medical needs. The list includes Alveus Therapeutics, Beacon Therapeutics, EpiBiologics, Expedition Medicines, Freya Biosciences, Infinimmune, Neomorph, Nuclidium, Pelage Pharmaceuticals, ReproNovo, and SonoThera. These companies span therapeutic areas including obesity, eye disease, oncology, immunology, reproductive health, and radiopharmaceuticals. The selection reflects a broader industry trend of capital returning to early-stage biotech, with several companies securing significant funding rounds and partnerships with major pharmaceutical firms.

Skin Dimpling: A Critical but Often Overlooked Breast Cancer Warning Sign
health10 days ago

Skin Dimpling: A Critical but Often Overlooked Breast Cancer Warning Sign

A breast oncologist warns that skin dimpling is a critical, often overlooked sign of breast cancer that requires immediate medical evaluation. While the World Health Organization reports that 2.4 million women are diagnosed globally each year, many cases lack specific risk factors beyond age and sex. Early detection through monitoring subtle changes like skin texture is vital, as untreated cancer can metastasize. Recent cases, such as actor Amanda Peet’s, highlight that skin changes can precede lumps, underscoring the need for vigilant self-examination and professional screening.

FDA Approves First RAS Inhibitor, Doubling Survival for Pancreatic Cancer Patients
health13 days ago

FDA Approves First RAS Inhibitor, Doubling Survival for Pancreatic Cancer Patients

The FDA has approved daraxonrasib (Rasonque), the first drug in its class to target RAS mutations, a breakthrough for pancreatic cancer. In a trial of 500 patients, the drug doubled median survival to 13.2 months compared to 6.7 months for chemotherapy. Developed by Revolution Medicines, the drug addresses a target previously deemed untargetable, offering new hope for a disease with a 13% five-year survival rate.

Merck Secures Global Rights to SciBrunch’s KRAS G12D Inhibitor in $2.13B Deal
pharma14 days ago

Merck Secures Global Rights to SciBrunch’s KRAS G12D Inhibitor in $2.13B Deal

Merck & Co. has acquired worldwide rights to SPR2015, a preclinical KRAS G12D inhibitor from Shanghai-based biotech SciBrunch, for an upfront payment of $400 million and potential total value of $2.13 billion. The deal, which closed in September 2026, positions Merck to expand its oncology pipeline beyond its existing KRAS G12C inhibitor, calderasib, while SciBrunch secures its first major partnership. SPR2015 is designed to target a prevalent mutation found in approximately 38% of pancreatic cancer patients and is expected to enter human trials by the end of 2026.

CAR T Cell Therapy Evolves: From Blood Cancer Success to Solid Tumor Challenges
health17 days ago

CAR T Cell Therapy Evolves: From Blood Cancer Success to Solid Tumor Challenges

CAR T cell therapy has transformed blood cancer treatment, achieving high survival rates, but faces hurdles in cost, side effects, and expanding to solid tumors. Recent FDA approvals for myeloma and myeloproliferative disorders highlight broader immunotherapy advances, while experts debate next-generation designs and accessibility.

AI in Oncology: From Hype to Curated Clinical Tools Amid a Data Tsunami
health-and-technology19 days ago

AI in Oncology: From Hype to Curated Clinical Tools Amid a Data Tsunami

Artificial intelligence is increasingly used in cancer care, but its impact varies from promising detection tools to curated clinical decision support. While big tech promises cures, practical applications focus on managing information overload, with tools like Onqo Health's Easy Oncology gaining traction among oncologists. AI excels in pattern recognition but faces risks of bias and overreliance, necessitating human oversight.