Early Therapy Switching Could Foil Cancer Resistance, Researchers Say

A new strategy proposes changing cancer therapies while tumors are still shrinking, using evolutionary modeling to prevent resistant cells from taking over. By not waiting for relapse, doctors could shorten the window for resistance to develop; three small clinical trials are underway, and models suggest that sequences of two or more therapies may outperform current practice, especially for larger tumors, though further lab and patient trials are needed to validate the approach.