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Engineered biologics win FDA nod, opening doors across the blood–brain barrier

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Source: Nature
Engineered biologics win FDA nod, opening doors across the blood–brain barrier
Photo: Nature
TL;DR Summary

The first FDA-approved engineered biologic that can cross the blood–brain barrier marks a milestone in CNS drug delivery, as researchers accelerate brain-shuttle approaches to ferry large-molecule therapies into the brain for potential treatments of neurological diseases.

Topics:health#biologics#blood-brain-barrier#cns#drug-delivery#fda-approval#science
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  1. Brain-shuttle biologics chart new paths across the blood–brain barrier  Nature
  2. The blood-brain barrier lets glucose and ketones cross freely, but blocks 98% of small-molecule drugs — and the tight junctions doing the filtering are only about 4 nanometers wide  ScienceBlog.com
  3. Blood-Brain Barrier Crossed: Denali’s FDA Approval Unlocks Alzheimer’s Pipeline  Tech Times
  4. Denali CEO to open AAIC 2026 with brain-delivery plan for Alzheimer’s  Stock Titan

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