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Drug Delivery

All articles tagged with #drug delivery

Spider Silk Inspires Next-Gen Medical Materials for Drug Delivery and Wound Repair
science21 days ago

Spider Silk Inspires Next-Gen Medical Materials for Drug Delivery and Wound Repair

Spider silk is guiding the development of new medical materials. Researchers extract silk genes and produce engineered silk proteins in microbes to create particles, gels, fibers, and 3D-printed scaffolds for drug delivery and tissue repair. These silk-based systems can biodegrade and release medicines over time, while providing biocompatible scaffolds that support cell growth and healing, with applications ranging from wound coverings to bone regeneration. The process leverages room‑temperature, water-based manufacturing that contrasts with traditional synthetic fibers.

via The Conversation|
#biomaterials#drug-delivery#science
Sugar-Coated Nanoparticles Deliver mRNA to Brain Tumors in Mice
science1 month ago

Sugar-Coated Nanoparticles Deliver mRNA to Brain Tumors in Mice

Researchers at Oregon State University used mannose-cholesterol coated lipid nanoparticles to cross the blood–brain barrier and deliver tumor-suppressing PTEN mRNA to glioblastoma in mice, greatly reducing tumor burden and extending survival without detectable organ toxicity. While promising, the results are preclinical and in animals, but the approach could become a general platform for brain-targeted mRNA therapies and other neurological applications.

via ScienceAlert|
#blood-brain-barrier#drug-delivery#glioblastoma
Injectable slow-release therapy reverses osteoarthritis in animal tests
science4 months ago

Injectable slow-release therapy reverses osteoarthritis in animal tests

UC Boulder researchers have developed a slow-release injectable therapy that prompts joint cells to repair cartilage and bone, reversing osteoarthritis in animal models within weeks. They’ve completed the first phase of experiments and are moving to safety/toxicity studies to enable human trials—potentially within 18 months—funded by ARPA-H’s NITRO program, as they pursue options beyond pain management and joint replacement.

via ScienceAlert|
#cartilage#clinical-trials#drug-delivery
Pig semen exosomes shown to shuttle chemo to back-of-eye cancer in mice
health4 months ago

Pig semen exosomes shown to shuttle chemo to back-of-eye cancer in mice

Researchers used semen-derived exosomes from pig semen to deliver a chemotherapy-like payload to the retina in a mouse model of retinoblastoma, via eye drops. The approach successfully reached the back of the eye and reduced tumor size after 30 days, suggesting a potential noninvasive treatment route for this pediatric eye cancer, though safety and effectiveness in humans remain to be tested in trials.

via Live Science|
#drug-delivery#eye-disease#health
Programmable DNA nanorobots target cancer and viruses in the bloodstream
science5 months ago

Programmable DNA nanorobots target cancer and viruses in the bloodstream

Scientists are turning DNA into programmable nanomachines that can move, sense, and deliver therapies, using DNA origami and strand displacement to create DNA robots that could autonomously seek out cancer cells or viruses in the bloodstream; while early demonstrations show targeted drug delivery and precise nanoparticle placement, major challenges remain in controlling motion, ensuring stability in the body, and scaling production for real-world medical use.

via Earth.com|
#biotechnology#dna-origami#dna-robots
Gut-Penetrating Peptide Brings Insulin Closer to an Oral Pill
science5 months ago

Gut-Penetrating Peptide Brings Insulin Closer to an Oral Pill

Researchers at Kumamoto University developed a cyclic DNP peptide that enables insulin to cross the intestinal barrier, achieving about 33–41% oral bioavailability in diabetic mouse models. They demonstrated two approaches—a mixing method where the peptide interacts with zinc-stabilized insulin hexamers, and a covalent DNP–insulin conjugate created via click chemistry—both producing effective glucose lowering. Once-daily dosing maintained normal glycemia for three days, marking a significant step toward practical oral insulin and potentially reducing injectable insulin needs; translational studies in larger animals and human intestinal systems are planned.

via SciTechDaily|
#diabetes#drug-delivery#insulin-bioavailability
Two Labs, One Bassline: Pink Floyd Tracks Breakthroughs in Brain Research
science6 months ago

Two Labs, One Bassline: Pink Floyd Tracks Breakthroughs in Brain Research

Two independent labs—UC Berkeley and Technion—used Pink Floyd’s 'Another Brick in the Wall, Part 1' as a test stimulus to probe brain activity and delivery science: Berkeley reconstructed the song from intracranial recordings, while Technion showed that low-frequency sound can influence cellular uptake and gene expression in neurons and mice via lipid nanoparticles, with fMRI showing brain activation in humans. The shared choice of a bass-heavy track underscores bass as a meaningful signal, but the work is exploratory, not therapeutic, with translational questions and limited quantitative data remaining.

via Headphonesty|
#brain#drug-delivery#music
Innovative Treatment Achieves 82% Success in Bladder Cancer Cure
health9 months ago

Innovative Treatment Achieves 82% Success in Bladder Cancer Cure

A new implant called TAR-200 has shown promising results in a phase 2 trial, eliminating tumors in 82% of high-risk bladder cancer patients resistant to previous treatments, with most tumors disappearing within three months and many patients remaining cancer-free after a year, offering a potentially safer and more effective alternative to traditional therapies.

via ScienceDaily|
#bladder-cancer#cancer-treatment#clinical-trial