All articles tagged with #drug delivery
Researchers used semen-derived exosomes from pig semen to deliver a chemotherapy-like payload to the retina in a mouse model of retinoblastoma, via eye drops. The approach successfully reached the back of the eye and reduced tumor size after 30 days, suggesting a potential noninvasive treatment route for this pediatric eye cancer, though safety and effectiveness in humans remain to be tested in trials.
Scientists are turning DNA into programmable nanomachines that can move, sense, and deliver therapies, using DNA origami and strand displacement to create DNA robots that could autonomously seek out cancer cells or viruses in the bloodstream; while early demonstrations show targeted drug delivery and precise nanoparticle placement, major challenges remain in controlling motion, ensuring stability in the body, and scaling production for real-world medical use.
Researchers at Kumamoto University developed a cyclic DNP peptide that enables insulin to cross the intestinal barrier, achieving about 33–41% oral bioavailability in diabetic mouse models. They demonstrated two approaches—a mixing method where the peptide interacts with zinc-stabilized insulin hexamers, and a covalent DNP–insulin conjugate created via click chemistry—both producing effective glucose lowering. Once-daily dosing maintained normal glycemia for three days, marking a significant step toward practical oral insulin and potentially reducing injectable insulin needs; translational studies in larger animals and human intestinal systems are planned.
Two independent labs—UC Berkeley and Technion—used Pink Floyd’s 'Another Brick in the Wall, Part 1' as a test stimulus to probe brain activity and delivery science: Berkeley reconstructed the song from intracranial recordings, while Technion showed that low-frequency sound can influence cellular uptake and gene expression in neurons and mice via lipid nanoparticles, with fMRI showing brain activation in humans. The shared choice of a bass-heavy track underscores bass as a meaningful signal, but the work is exploratory, not therapeutic, with translational questions and limited quantitative data remaining.
Researchers are investigating how cancer uses extracellular vesicles to colonize new organs and are creating artificial liposomes that mimic these vesicles to observe uptake by cancer cells in real time, with the goal of delivering targeted therapies and ultimately blocking metastasis while improving drug delivery.
A new implant called TAR-200 has shown promising results in a phase 2 trial, eliminating tumors in 82% of high-risk bladder cancer patients resistant to previous treatments, with most tumors disappearing within three months and many patients remaining cancer-free after a year, offering a potentially safer and more effective alternative to traditional therapies.
LaMar Cook, a former deputy director for the governor’s regional office in Springfield, was arraigned on charges of cocaine trafficking, gun possession without a license, and driving without a license after receiving a large drug delivery at the state building.
A study from Texas Tech found that the blood-brain barrier remains largely intact in a common mouse model of Alzheimer's, challenging previous beliefs that the disease causes widespread BBB leakiness, which has implications for drug delivery strategies.
Cambridge researchers have developed a pH-sensitive gel that can detect inflammation in joints and release anti-inflammatory drugs precisely where needed, potentially revolutionizing arthritis treatment by reducing side effects and improving efficacy, though clinical trials are still required.
University scientists in Chicago have developed a new nanostructure called LNP-SNA that triples CRISPR's ability to enter cells, significantly improving gene editing efficiency and safety, which could enhance treatments for genetic diseases.
Scientists at Northwestern University developed lipid nanoparticle spherical nucleic acids (LNP-SNAs) that significantly improve CRISPR delivery into cells, tripling gene-editing efficiency, reducing toxicity, and enhancing the potential for safer genetic medicines.
Scientists are exploring the use of pollen grains, transformed into a versatile microgel, for eco-friendly applications such as sustainable paper, films, sponges, and drug delivery systems, offering a resource-efficient alternative to traditional materials.
A new slow-release drug system called TAR-200 has shown to eliminate bladder cancer in 82% of patients in a clinical trial, especially effective for those unresponsive to traditional therapies, with the potential for FDA approval and improved quality of life for patients.
Affidavits reveal details in a quadruple homicide case in Lake County, involving Austin Drummond and others, with evidence of drug-related activities and accessory after the fact by Dearrah Sanders.
Scientists from the University of South Australia have developed a biodegradable, long-acting injectable gel that delivers levodopa and carbidopa steadily over a week, potentially transforming Parkinson's treatment by reducing dosing frequency and improving patient compliance. The formulation has shown promising safety and effectiveness in lab tests, with plans for clinical trials and commercialization.