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Blood Brain Barrier

All articles tagged with #blood brain barrier

Nanoparticles Restore Brain Cleanup, Reversing Alzheimer’s Signs in Mice
science9 days ago

Nanoparticles Restore Brain Cleanup, Reversing Alzheimer’s Signs in Mice

Researchers used supramolecular nanoparticles that act as drugs to repair the brain's blood-brain barrier and restart its waste-clearance system. In mice with high amyloid-β, three injections reduced brain Aβ by 50–60% within an hour, with months-long vascular and cognitive improvements; the approach leverages the LRP1 transport system to reset clearance. While promising, the work is in animal studies and human trials remain years away.

via ScienceDaily|
#alzheimers-disease#amyloid-beta#blood-brain-barrier
Self-organizing laser beam enables ultrafast, high-res brain imaging
technology28 days ago

Self-organizing laser beam enables ultrafast, high-res brain imaging

MIT researchers reveal a laser that self-organizes into a stable pencil beam inside a multimode fiber under precise on-axis high-power conditions, enabling ultrafast, high-resolution 3D imaging of the blood–brain barrier and real-time tracking of drug uptake without fluorescent tags—potentially speeding brain-targeted therapy research by about 25x and opening paths to imaging neurons and other tissues.

via MIT News|
#bioimaging#blood-brain-barrier#nonlinear-optics
Exercise Fuels a Brain-Protection Pathway That Fights Alzheimer’s (Mouse Study)
science2 months ago

Exercise Fuels a Brain-Protection Pathway That Fights Alzheimer’s (Mouse Study)

A UCSF study in mice shows exercise increases GPLD1 in the blood, which helps prune TNAP in brain blood vessels, strengthening the blood-brain barrier, reducing inflammation, and lowering amyloid beta clumps associated with Alzheimer's. The findings suggest a body-brain mechanism behind exercise’s cognitive benefits and point to potential therapies that mimic GPLD1, though human relevance remains to be confirmed.

via ScienceAlert|
#alzheimers#blood-brain-barrier#exercise
Brain gatekeepers clear tau: Alzheimer’s may cripple this cleanup
science2 months ago

Brain gatekeepers clear tau: Alzheimer’s may cripple this cleanup

Specialized brain cells called tanycytes clear tau proteins from cerebrospinal fluid into the bloodstream, helping remove potentially toxic tau from the brain. In Alzheimer's disease, tanycytes are damaged and less tau moves to the blood, correlating with brain tau buildup; this reveals a potential mechanism for disease progression and a new target to boost tau clearance.

via Nature|
#alzheimers-disease#blood-brain-barrier#csf
Workout-Driven Shield: How Exercise Tightens the Brain’s Barrier to Preserve Memory
science3 months ago

Workout-Driven Shield: How Exercise Tightens the Brain’s Barrier to Preserve Memory

UC San Francisco researchers show that exercise increases the liver enzyme GPLD1, which travels to brain blood vessels and removes TNAP from the blood-brain barrier. This restores barrier integrity and reduces leakiness and inflammation in aging mice, helping memory and cognitive performance, and suggesting new therapeutic avenues for aging and Alzheimer’s-related decline.

via SciTechDaily|
#aging#blood-brain-barrier#exercise
Erythritol May Undermine Brain Shield, Raise Stroke Risk
science3 months ago

Erythritol May Undermine Brain Shield, Raise Stroke Risk

New lab and observational evidence suggests the sugar substitute erythritol can damage cells of the blood-brain barrier, trigger oxidative stress, and lower nitric oxide while raising endothelin-1, potentially narrowing cerebral vessels and hindering clot dissolution—factors that could elevate stroke risk; these findings align with studies linking erythritol to higher cardiovascular events, though most experiments used isolated cells and require validation in more realistic models.

via ScienceAlert|
#blood-brain-barrier#cardiovascular-health#erythritol
Systemic Peptide Therapy Reduces Brain Damage After Stroke in Mice
science4 months ago

Systemic Peptide Therapy Reduces Brain Damage After Stroke in Mice

Researchers tested IKVAV-PA, a peptide-based nanomaterial, in a mouse model of acute ischemic stroke and found that systemic delivery allows the molecules to cross the blood-brain barrier and reduce brain tissue damage, inflammation, and harmful immune responses after reperfusion, indicating potential as an adjunct therapy—though human safety and long-term efficacy remain to be studied.

via ScienceAlert|
#blood-brain-barrier#neural-repair#neuroprotection
Cancer-produced protein dissolves Alzheimer’s plaques in mice, hinting at new treatments
science4 months ago

Cancer-produced protein dissolves Alzheimer’s plaques in mice, hinting at new treatments

A Cell study (15 years in the making) finds that a protein called cystatin C, produced by cancer cells, can cross the blood–brain barrier and help break apart amyloid plaques in mouse models of Alzheimer’s disease, offering a possible explanation for the observed link between cancer and lower Alzheimer’s risk and suggesting a new avenue for drug development—though the findings are preclinical and in animals.

via Nature|
#alzheimers-disease#amyloid-plaques#blood-brain-barrier
Dancing Peptides Cross the Blood-Brain Barrier to Repair Stroke Damage in Mice
science4 months ago

Dancing Peptides Cross the Blood-Brain Barrier to Repair Stroke Damage in Mice

Northwestern researchers developed an intravenously delivered supramolecular peptide therapy, IKVAV-PA, that crosses the blood-brain barrier after a stroke, accumulates at injury sites, and reduces tissue damage and inflammation in mice with a single post-reperfusion dose, without detectable organ toxicity. While no short-term behavioral improvement was seen, the approach shows promise as an adjunct to clot-reopening treatments and could extend to other brain injuries pending longer-term studies on cognitive and functional recovery.

via Indian Defence Review|
#blood-brain-barrier#ikvav-pa#nanomaterials
Dancing-molecule nanotherapy crosses the blood-brain barrier to repair stroke damage
science4 months ago

Dancing-molecule nanotherapy crosses the blood-brain barrier to repair stroke damage

Northwestern researchers have developed an injectable regenerative nanomaterial built from dynamic “dancing molecules” that can cross the blood-brain barrier after reperfusion in a mouse model of ischemic stroke. Delivered intravenously immediately after clot removal, the therapy reduced brain damage and inflammation without observed toxicity, suggesting it could complement clot-busting treatments. The approach relies on smaller peptide assemblies crossing the BBB before larger nanofibers form in brain tissue, and may have implications for traumatic brain injury and neurodegenerative diseases. Next steps include longer-term functional studies and exploring additional regenerative signals.

via SciTechDaily|
#blood-brain-barrier#nanomedicine#regenerative-medicine
Molecular Insights into Brain Endothelial-Astrocyte Communication in Mice and Humans
neuroscience6 months ago

Molecular Insights into Brain Endothelial-Astrocyte Communication in Mice and Humans

This study used molecular profiling and innovative proteomics techniques to explore how brain endothelial cells communicate with astrocyte endfeet in mice and humans, revealing dynamic ligand-receptor interactions that are modulated during peripheral inflammation and are conserved across species, with implications for understanding neuroinflammatory and neurodegenerative diseases.

via Nature|
#astrocyte-endfeet#blood-brain-barrier#brain-endothelial-cells