Engineered DNA payload targets glioblastoma with immune boost via viral delivery
TL;DR Summary
A Nature News & Views piece describes Koeber et al.'s strategy to selectively kill glioblastoma cells by using a virus to deliver an engineered DNA sequence that encodes a protein needed for a drug to kill the tumor, plus a cytokine to rally the immune system; in mice, this viral cargo eliminated brain tumours, offering a potential targeted cancer therapy that aims to spare healthy tissue.
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