All articles tagged with #glioblastoma
MimiVax's experimental cancer vaccine SurVaxM failed to meet its primary endpoint in a Phase 2b trial for glioblastoma, showing a median overall survival of 22.8 months versus 20.3 months for placebo. However, the drug demonstrated statistically significant survival benefits in patients aged 65 and under, prompting the company to seek FDA approval.
MimiVax reported that its experimental vaccine SurVaxM failed to meet the primary endpoint in a phase 2 trial for glioblastoma, an aggressive brain cancer. While overall survival did not significantly improve across the full study group, data for patients aged 65 and younger showed a meaningful survival benefit, leading the company to pursue FDA approval.
Researchers at Caltech have developed a trimodal ultrasound technique to observe glioblastoma growth in real-time within the brains of awake mice. By engineering tumor cells to produce gas vesicles, the team could track how the cancer displaces healthy tissue and remodels blood vessels over an 11-day period. This non-invasive method offers a new way to study the physical interactions between tumors and the brain, potentially aiding future treatment strategies.
Northwell Health researchers found that a medically supervised diet modeled after treatment for GAMT deficiency—restricting arginine and boosting ornithine to curb the production of guanidinoacetate (GAA)—slowed glioma growth in mice, a result that could lead to pre-surgical testing in humans, with a clinical trial planned for 2027.
Mike McFarland, the Texas‑based voice actor famed for Master Roshi and Najirobe in Dragon Ball/DBZ and Buggy the Clown in One Piece, died at 56 from glioblastoma brain cancer after being diagnosed in 2025; a prolific writer, director and producer, he helped shape Funimation and Crunchyroll’s anime production and credited roles across a wide range of series.
In preclinical models, blocking the SET protein reactivates the tumor-suppressing enzyme PP2A, reducing glioblastoma growth and making cancer cells more sensitive to radiation, offering a potential way to enhance standard therapies; human trials are needed to assess safety and efficacy.
A 34-year-old Welshman, Joshua Smith, experienced brain fog and a 10-day migraine that doctors initially dismissed; after repeated ER visits, imaging revealed a brain mass later diagnosed as glioblastoma. He underwent surgery to remove about 95% of the tumor and is now undergoing chemotherapy and radiotherapy with regular MRI monitoring. His wife, Kelly, is raising funds for brain tumor research, sharing their journey to raise awareness and support trials and treatments abroad.
In a mouse model of glioblastoma, researchers loaded the chemotherapy drug doxorubicin into standard liposome nanoparticles and administered it soon after tumor resection. The temporary disruption of the blood-brain barrier allowed the liposome-encapsulated drug to accumulate at the tumor margin for up to 72 hours, with levels undetectable after seven days, suggesting a practical post-surgical delivery window and a potentially translatable, low-tech nanomedicine approach that could move toward human trials.
Josh Smith, 34, from Wrexham was diagnosed with terminal glioblastoma after months of headaches; surgeons removed 95% of a 4.5 cm tumor and he’s undergone radiotherapy and ongoing chemotherapy. Despite a prognosis of 12–18 months, he and wife Kelly are making every day count—climbing Snowdon, parkruns and other activities—while lobbying for more brain tumour research funding in Wales as the government plans a cancer strategy focused on research and trials.
A study shows that a low-carbohydrate, high-fat diet can curb glioblastoma growth by shifting brain lipid availability and restricting fatty acid oxidation in glioblastoma stem cells; the diet also reshapes the gut microbiome and circadian networks, offering a non-pharmacologic strategy to delay recurrence when used around the standard postoperative treatment.
Four people developed glioblastoma, including three longtime Philadelphia narcotics officers; all died within years of each other. Their shared thread appears to be years spent in the narcotics unit and a possible link to the shuttered Frankford Arsenal site in Philadelphia (closed in the 1970s and now housing a high school and other businesses). Investigators are examining whether environmental exposures at the former Army ammunition plant could explain the rare cancer cluster.
Researchers at Oregon State University used mannose-cholesterol coated lipid nanoparticles to cross the blood–brain barrier and deliver tumor-suppressing PTEN mRNA to glioblastoma in mice, greatly reducing tumor burden and extending survival without detectable organ toxicity. While promising, the results are preclinical and in animals, but the approach could become a general platform for brain-targeted mRNA therapies and other neurological applications.
Researchers report that a vitamin B12–based compound, nitrosylcobalamin (NO-Cbl), can cross the blood-brain barrier, selectively accumulate in glioblastoma tumors, and deliver nitric oxide to cancer cells in preclinical models; it also shows synergistic activity with temozolomide (and TRAIL) to enhance tumor suppression, offering a promising but early approach that requires further validation before clinical use.
Former Marlins president David Samson revealed his 28-year-old daughter Kyra died after a yearlong fight with glioblastoma brain cancer. He had publicly shared her illness on his Nothing Personal podcast and urged donations to The Kyra Fund, which has raised over $158,000 of a $200,000 goal to support glioblastoma research.
During a June 2026 episode of Watch What Happens Live, Andy Cohen fought back tears as he paid tribute to Kyra Samson, a longtime WWHL production manager who died at 28 from brain cancer. He recalled her warmth, urged viewers to donate to the Kyra Fund for glioblastoma research, and sent prayers to her family, highlighting the close-knit WWHL community.