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Glioblastoma

All articles tagged with #glioblastoma

Ten-Day Migraine Unmasks Glioblastoma in 34-Year-Old Welshman
health25 days ago

Ten-Day Migraine Unmasks Glioblastoma in 34-Year-Old Welshman

A 34-year-old Welshman, Joshua Smith, experienced brain fog and a 10-day migraine that doctors initially dismissed; after repeated ER visits, imaging revealed a brain mass later diagnosed as glioblastoma. He underwent surgery to remove about 95% of the tumor and is now undergoing chemotherapy and radiotherapy with regular MRI monitoring. His wife, Kelly, is raising funds for brain tumor research, sharing their journey to raise awareness and support trials and treatments abroad.

via Yahoo|
#brain-cancer#brain-tumor#fundraising
Low-tech liposomes enable brain-penetrant chemotherapy after glioblastoma surgery
science26 days ago

Low-tech liposomes enable brain-penetrant chemotherapy after glioblastoma surgery

In a mouse model of glioblastoma, researchers loaded the chemotherapy drug doxorubicin into standard liposome nanoparticles and administered it soon after tumor resection. The temporary disruption of the blood-brain barrier allowed the liposome-encapsulated drug to accumulate at the tumor margin for up to 72 hours, with levels undetectable after seven days, suggesting a practical post-surgical delivery window and a potentially translatable, low-tech nanomedicine approach that could move toward human trials.

via Fierce Biotech|
#blood-brain-barrier#doxorubicin#glioblastoma
Wrexham man with terminal glioblastoma makes every day count
health27 days ago

Wrexham man with terminal glioblastoma makes every day count

Josh Smith, 34, from Wrexham was diagnosed with terminal glioblastoma after months of headaches; surgeons removed 95% of a 4.5 cm tumor and he’s undergone radiotherapy and ongoing chemotherapy. Despite a prognosis of 12–18 months, he and wife Kelly are making every day count—climbing Snowdon, parkruns and other activities—while lobbying for more brain tumour research funding in Wales as the government plans a cancer strategy focused on research and trials.

via BBC|
#brain-cancer#brain-tumour-research#glioblastoma
Low-carb, high-fat diet throttles glioblastoma by redefining tumor lipids and stem-cell metabolism
science28 days ago

Low-carb, high-fat diet throttles glioblastoma by redefining tumor lipids and stem-cell metabolism

A study shows that a low-carbohydrate, high-fat diet can curb glioblastoma growth by shifting brain lipid availability and restricting fatty acid oxidation in glioblastoma stem cells; the diet also reshapes the gut microbiome and circadian networks, offering a non-pharmacologic strategy to delay recurrence when used around the standard postoperative treatment.

via Nature|
#cancer-metabolism#fatty-acid-oxidation#glioblastoma
Brain-cancer cluster tied to shuttered Philadelphia ammo plant puzzles investigators
health1 month ago

Brain-cancer cluster tied to shuttered Philadelphia ammo plant puzzles investigators

Four people developed glioblastoma, including three longtime Philadelphia narcotics officers; all died within years of each other. Their shared thread appears to be years spent in the narcotics unit and a possible link to the shuttered Frankford Arsenal site in Philadelphia (closed in the 1970s and now housing a high school and other businesses). Investigators are examining whether environmental exposures at the former Army ammunition plant could explain the rare cancer cluster.

via NBC News|
#brain-cancer#environmental-exposure#frankford-arsenal
Sugar-Coated Nanoparticles Deliver mRNA to Brain Tumors in Mice
science1 month ago

Sugar-Coated Nanoparticles Deliver mRNA to Brain Tumors in Mice

Researchers at Oregon State University used mannose-cholesterol coated lipid nanoparticles to cross the blood–brain barrier and deliver tumor-suppressing PTEN mRNA to glioblastoma in mice, greatly reducing tumor burden and extending survival without detectable organ toxicity. While promising, the results are preclinical and in animals, but the approach could become a general platform for brain-targeted mRNA therapies and other neurological applications.

via ScienceAlert|
#blood-brain-barrier#drug-delivery#glioblastoma
Vitamin B12–Derived Therapy Penetrates Brain Barrier to Target Glioblastoma
health-and-medicine1 month ago

Vitamin B12–Derived Therapy Penetrates Brain Barrier to Target Glioblastoma

Researchers report that a vitamin B12–based compound, nitrosylcobalamin (NO-Cbl), can cross the blood-brain barrier, selectively accumulate in glioblastoma tumors, and deliver nitric oxide to cancer cells in preclinical models; it also shows synergistic activity with temozolomide (and TRAIL) to enhance tumor suppression, offering a promising but early approach that requires further validation before clinical use.

via ScienceDaily|
#blood-brain-barrier#glioblastoma#health-and-medicine
Andy Cohen Remembers WWHL Staffer Kyra Samson With Tearful Tribute
entertainment2 months ago

Andy Cohen Remembers WWHL Staffer Kyra Samson With Tearful Tribute

During a June 2026 episode of Watch What Happens Live, Andy Cohen fought back tears as he paid tribute to Kyra Samson, a longtime WWHL production manager who died at 28 from brain cancer. He recalled her warmth, urged viewers to donate to the Kyra Fund for glioblastoma research, and sent prayers to her family, highlighting the close-knit WWHL community.

via Yahoo|
#andy-cohen#entertainment#glioblastoma
Brain Cancer Vaccine Yields Long-Term Survival in About a Quarter of Patients
health2 months ago

Brain Cancer Vaccine Yields Long-Term Survival in About a Quarter of Patients

A UCLA-led immunotherapy approach for glioblastoma exposes a patient’s white blood cells to tumor cells outside the brain, then reinfuses them as a vaccine. From 2003–2019 trials, 331 patients received the vaccine and 20–25% survived years longer, with 2023 JAMA Oncology results prompting further study of why some patients respond. Researchers are examining biomarkers like MGMT methylation and the gut microbiome to predict benefit. The work, led by Dr. Linda Liau, has earned recognition in medicine and reflects her personal drive born from family experience with brain cancer.

via Brown Alumni Magazine|
#brain-tumor#cancer-vaccine#glioblastoma
GABA-Driven Immunosuppression Sparks Female-Specific GBM Growth
science2 months ago

GABA-Driven Immunosuppression Sparks Female-Specific GBM Growth

Researchers at the University of Miami found that glioblastoma grows via a female-specific mechanism in which the neurotransmitter GABA reprograms granulocytic myeloid-derived suppressor cells (MDSCs) to become more immunosuppressive, promoting tumor growth only in females. Blocking GABA receptors in female models dismantled this immune shield and improved survival, with human tumor samples showing higher GABA and GABA receptor levels in female granulocytic MDSCs. The findings suggest sex-specific immunotherapy approaches for brain cancer and potential broader applications to other tumors that recruit MDSCs.

via Neuroscience News|
#gaba#glioblastoma#immunotherapy
Jill Smokler, Scary Mommy Founder, Dies at 48 After Brain Cancer Battle
obituaries2 months ago

Jill Smokler, Scary Mommy Founder, Dies at 48 After Brain Cancer Battle

Jill Smokler, the Baltimore-area mom who created Scary Mommy in 2008 and turned it into a candid, millions-strong platform about the imperfect side of parenting, died at 48 from glioblastoma diagnosed in 2024. She built a media brand, wrote best-selling books, and sold Scary Mommy in a multimillion-dollar deal in 2015 while remaining its chief content officer. She is survived by her three children, brother, and parents; her marriage ended in 2017. Smokler’s work challenged the myth of work-life balance by embracing the messy realities of motherhood.

via The New York Times|
#blogging#glioblastoma#jill-smokler
From Misdiagnosis to Glioblastoma: A Mother's Battle and a Son's Fight for a Cure
health2 months ago

From Misdiagnosis to Glioblastoma: A Mother's Battle and a Son's Fight for a Cure

Michelle Dilger’s symptoms were first dismissed as menopause and anxiety, but in 2018 she was diagnosed with glioblastoma, undergoing 13 brain surgeries plus radiation and chemotherapy over two years. Despite a grim prognosis, she beat the odds, inspiring her son to launch Cramp Killa to support Brain Tumour Research and raise awareness for glioblastoma research.

via Yahoo|
#brain-cancer#brain-surgeries#glioblastoma
Tiny brain implant fights brain cancer with electrical therapy
technology2 months ago

Tiny brain implant fights brain cancer with electrical therapy

Coherence Neuro, a San Francisco biotech tied to Neuralink, began testing a coin-sized brain implant by placing it temporarily in three patients undergoing brain-tumor surgery in Australia to sense tumor electrical activity and deliver mild stimulation aimed at slowing growth. The 30-minute implants, used as a safety check before longer-term use, could enable continuous monitoring and remote adjustment via an app, with plans for a permanent implant trial in glioblastoma patients next year, potentially offering a more convenient alternative to existing devices like Optune.

via WIRED|
#brain-cancer#brain-computer-interface#clinical-trial