Exercise Reboots Aging Muscles by Lowering DEAF1, Restoring Repair
TL;DR Summary
New Duke-NUS research shows exercise can reverse aging-related muscle decline by lowering DEAF1, which otherwise drives excessive mTORC1 activity and damaged-protein buildup. By rebalancing protein production and removal, exercise helps aging muscles repair and stay stronger, a result seen in fruit flies and older mice. The benefit may be limited when DEAF1 is very high or FOXO activity is too low, suggesting potential therapies that mimic exercise.
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- Exercise May Help Aging Muscles Fight Cancer Yahoo
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