Exercise Reboots Aging Muscles by Lowering DEAF1, Restoring Repair
TL;DR
New Duke-NUS research shows exercise can reverse aging-related muscle decline by lowering DEAF1, which otherwise drives excessive mTORC1 activity and damaged-protein buildup. By rebalancing protein production and removal, exercise helps aging muscles repair and stay stronger, a result seen in fruit flies and older mice. The benefit may be limited when DEAF1 is very high or FOXO activity is too low, suggesting potential therapies that mimic exercise.
- Scientists discover why exercise reverses muscle aging ScienceDaily
- Delayed molecular aging, preservation of energy metabolism and enhanced exercise response in exercise-trained human muscle Nature
- 14 Hallmarks Of Ageing That Regular Exercise Can Slow Down HuffPost UK
- Exercise May Help Aging Muscles Fight Cancer Yahoo
- Exercise May Help Protect Older Adults Against Cancer The Good Men Project
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