Tag

Foxo

All articles tagged with #foxo

science5 days ago•4 min saved

Exercise Reboots Aging Muscles by Lowering DEAF1, Restoring Repair

New Duke-NUS research shows exercise can reverse aging-related muscle decline by lowering DEAF1, which otherwise drives excessive mTORC1 activity and damaged-protein buildup. By rebalancing protein production and removal, exercise helps aging muscles repair and stay stronger, a result seen in fruit flies and older mice. The benefit may be limited when DEAF1 is very high or FOXO activity is too low, suggesting potential therapies that mimic exercise.

via ScienceDaily|

#aging #deaf1 #exercise

health5 months ago•5 min saved

Exercise blocks aging muscle decline by silencing a key protein driver

New research shows that exercise helps prevent age-related muscle loss by suppressing the DEAF1 transcription factor that drives protein imbalance and triggering protective FOXO genes, which restore cellular repair and protein recycling. This balances mTORC1 activity to support maintenance rather than degeneration, with both resistance and aerobic training beneficial and a combination offering the greatest benefit. It’s never too late to start—regular activity can help older adults stay stronger and more mobile.

via Medical News Today|

#aging #deaf1 #exercise

neuroscience3 years ago•4 min saved

The Deadly Impact of Witnessing Death on Fruit Flies

Neuroscientists have identified the neural circuits and signaling processes behind the physiological effects, including rapid aging, that occur when fruit flies encounter their dead. They found that a handful of neurons in the Drosophila brain called R2/R4 neurons act as a rheostat for aging. Inhibiting or activating them changed the aging rate of the flies, suggesting that these neurons alter fly life span in response to perceiving dead flies. The study provides insight into the neural underpinnings of how the senses affect aging and could help researchers better understand the physiological and psychological effects of people who routinely witness death.

via The Conversation|

#aging #foxo #fruit-flies