Tag

Mtorc1

All articles tagged with #mtorc1

science2 months ago•4 min saved

Exercise Reboots Aging Muscles by Lowering DEAF1, Restoring Repair

New Duke-NUS research shows exercise can reverse aging-related muscle decline by lowering DEAF1, which otherwise drives excessive mTORC1 activity and damaged-protein buildup. By rebalancing protein production and removal, exercise helps aging muscles repair and stay stronger, a result seen in fruit flies and older mice. The benefit may be limited when DEAF1 is very high or FOXO activity is too low, suggesting potential therapies that mimic exercise.

via ScienceDaily|

#aging #deaf1 #exercise

science5 months ago•8 min saved

Exercise Rewinds Muscle Aging by Tuning a Key Genetic Switch

Researchers identify DEAF1 as a driver of aging-muscle decline through overactive mTORC1, which disrupts protein turnover. Exercise lowers DEAF1 via FOXO-regulated pathways, restoring balance and enabling damaged proteins to be cleared, helping aging muscles repair and stay stronger; however, high DEAF1 levels or very low FOXO activity can blunt exercise benefits. Findings from fruit flies and mice suggest potential therapies that mimic exercise to protect muscle health during aging or illness.

via SciTechDaily|

#deaf1 #exercise #foxos