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Exome study flags 36 high-impact genes for OCD and tic disorders

1 min read
Source: Nature
Exome study flags 36 high-impact genes for OCD and tic disorders
Photo: Nature
TL;DR Summary

A large whole-exome sequencing study of 3,964 individuals with OCD and chronic tic disorders (including 2,418 trios) finds enrichment of de novo and rare damaging coding variants and identifies 36 high-confidence risk genes using the TADA framework, expanding the genetic landscape beyond previously known genes and highlighting cross-disorder overlap and pathways related to synaptic biology.

Topics:health#de-novo-mutations#exome-sequencing#genetics#obsessive-compulsive-disorder#science#tourette-syndrome
Share this article
  1. Whole-exome sequencing in individuals with obsessive–compulsive disorder and chronic tic disorders identifies 36 large-effect risk genes  Nature
  2. Dozens of genes tied to OCD and tic disorders discovered  Medical Xpress
  3. Health Rounds: Scientists find genes linked to OCD, raising the prospect of new treatments  The Mighty 790 KFGO

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