Fat-derived molecules act as the body’s brake on inflammation

UCL researchers found that fat-derived epoxy-oxylipins regulate the immune response by inhibiting soluble epoxide hydrolase (sEH), increasing protective lipids, reducing intermediate monocytes linked to chronic inflammation, and speeding inflammation resolution in humans; a 12,13-EpOME pathway involving p38 MAPK suggests safer therapies for autoimmune and cardiovascular diseases, with potential clinical trials.