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P38 Mapk

All articles tagged with #p38 mapk

science14 days ago•8 min saved

Fat-Derived Molecules Act as the Body's Inflammation Brake

University College London researchers identified natural epoxy-oxylipins as an anti-inflammatory off-switch in humans. By blocking soluble epoxide hydrolase with GSK2256294, levels of these fat-derived molecules rise, dampening the expansion of intermediate monocytes via the p38 MAPK pathway, accelerating inflammation resolution without broadly suppressing immunity and suggesting safer therapeutic routes for diseases such as rheumatoid arthritis and cardiovascular disease.

via SciTechDaily|

#epoxy-oxylipins #inflammation #monocytes

science3 months ago•4 min saved

Fat-derived molecules act as the body’s brake on inflammation

UCL researchers found that fat-derived epoxy-oxylipins regulate the immune response by inhibiting soluble epoxide hydrolase (sEH), increasing protective lipids, reducing intermediate monocytes linked to chronic inflammation, and speeding inflammation resolution in humans; a 12,13-EpOME pathway involving p38 MAPK suggests safer therapies for autoimmune and cardiovascular diseases, with potential clinical trials.

via ScienceDaily|

#epoxy-oxylipins #inflammation #intermediate-monocytes

science4 months ago•4 min saved

Body's Natural Brake on Inflammation Identified, Hinting at Safer Treatments

A human study finds that fat-derived epoxy-oxylipins act as natural brakes on inflammation by preventing the buildup of intermediate monocytes. Blocking the enzyme soluble epoxide hydrolase (sEH) raises epoxy-oxylipin levels, speeding inflammation resolution and reducing harmful immune cell expansion, with the mechanism involving suppression of the p38 MAPK pathway. This points to safer, targeted therapies for chronic inflammatory diseases like arthritis and cardiovascular conditions.

via SciTechDaily|

#epoxy-oxylipins #inflammation #monocytes