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Epoxy Oxylipins

All articles tagged with #epoxy oxylipins

science27 days ago•5 min saved

Natural brake on inflammation found, hinting at safer anti-inflammatory drugs

Researchers at UCL identified epoxy-oxylipins as natural brakes that help end inflammation. Inhibiting the enzyme soluble epoxide hydrolase (sEH) raises epoxy-oxylipin levels, speeding pain resolution and reducing intermediate monocytes—cells linked to chronic inflammation—through suppression of the p38 MAPK pathway. The study, conducted in humans using a safe drug approach, points to safer, immune-balancing therapies and potential trials for autoimmune and cardiovascular diseases.

via Science Daily|

#epoxy-oxylipins #inflammation #intermediate-monocytes

science4 months ago•8 min saved

Fat-Derived Molecules Act as the Body's Inflammation Brake

University College London researchers identified natural epoxy-oxylipins as an anti-inflammatory off-switch in humans. By blocking soluble epoxide hydrolase with GSK2256294, levels of these fat-derived molecules rise, dampening the expansion of intermediate monocytes via the p38 MAPK pathway, accelerating inflammation resolution without broadly suppressing immunity and suggesting safer therapeutic routes for diseases such as rheumatoid arthritis and cardiovascular disease.

via SciTechDaily|

#epoxy-oxylipins #inflammation #monocytes

science7 months ago•4 min saved

Fat-derived molecules act as the body’s brake on inflammation

UCL researchers found that fat-derived epoxy-oxylipins regulate the immune response by inhibiting soluble epoxide hydrolase (sEH), increasing protective lipids, reducing intermediate monocytes linked to chronic inflammation, and speeding inflammation resolution in humans; a 12,13-EpOME pathway involving p38 MAPK suggests safer therapies for autoimmune and cardiovascular diseases, with potential clinical trials.

via ScienceDaily|

#epoxy-oxylipins #inflammation #intermediate-monocytes

science8 months ago•4 min saved

Body's Natural Brake on Inflammation Identified, Hinting at Safer Treatments

A human study finds that fat-derived epoxy-oxylipins act as natural brakes on inflammation by preventing the buildup of intermediate monocytes. Blocking the enzyme soluble epoxide hydrolase (sEH) raises epoxy-oxylipin levels, speeding inflammation resolution and reducing harmful immune cell expansion, with the mechanism involving suppression of the p38 MAPK pathway. This points to safer, targeted therapies for chronic inflammatory diseases like arthritis and cardiovascular conditions.

via SciTechDaily|

#epoxy-oxylipins #inflammation #monocytes