Fat-Derived Molecules Act as the Body's Inflammation Brake

University College London researchers identified natural epoxy-oxylipins as an anti-inflammatory off-switch in humans. By blocking soluble epoxide hydrolase with GSK2256294, levels of these fat-derived molecules rise, dampening the expansion of intermediate monocytes via the p38 MAPK pathway, accelerating inflammation resolution without broadly suppressing immunity and suggesting safer therapeutic routes for diseases such as rheumatoid arthritis and cardiovascular disease.