Tag

Monocytes

All articles tagged with #monocytes

science27 days ago•7 min saved

Midlife Brain Remodeling Rewrites Immune Landscape, Linking to Inflammation and Dementia Risk

A Science study of ~320,000 hippocampal cells from 40 healthy people aged 20–95 finds a midlife tipping point around age 50, where aging brains undergo extensive cellular remodeling: original microglia appear replaced by blood-derived monocytes, astrocytes lose energy-related activity and decline, and 3D genome organization degrades, leading to higher inflammation and a potential dementia risk, with some differences between men and women.

via sciencealert.com|

#aging #brain #hippocampus

science3 months ago•8 min saved

Fat-Derived Molecules Act as the Body's Inflammation Brake

University College London researchers identified natural epoxy-oxylipins as an anti-inflammatory off-switch in humans. By blocking soluble epoxide hydrolase with GSK2256294, levels of these fat-derived molecules rise, dampening the expansion of intermediate monocytes via the p38 MAPK pathway, accelerating inflammation resolution without broadly suppressing immunity and suggesting safer therapeutic routes for diseases such as rheumatoid arthritis and cardiovascular disease.

via SciTechDaily|

#epoxy-oxylipins #inflammation #monocytes

health-and-medicine4 months ago•6 min saved

New Monocyte State Tied to Long COVID Fatigue and Breathing Issues

A single-cell multiomics study of Long COVID patients found a distinct molecular state in CD14+ monocytes (LC-Mo), especially common in those who had mild-to-moderate initial infection. LC-Mo correlates with fatigue and respiratory symptoms and is linked to elevated cytokine levels, offering a new lead for personalized treatment and deeper understanding of Long COVID.

via ScienceDaily|

#cytokines #health-and-medicine #immune-system

health5 months ago•67 min saved

Immune signals and hormones may explain why women's pain lingers longer

New research combining mouse experiments with human vehicle‑crash data suggests that pain after injury lasts longer in women because monocytes produce less IL-10, a molecule that both reduces inflammation and directly dampens pain signals; testosterone boosts IL-10 production in male monocytes, helping men recover faster. This shifts the view of the immune system from solely driving pain to also helping resolve it, pointing to therapies that enhance the body's natural pain‑resolution pathways to prevent chronic pain.

via Live Science|

#health #immune-system #interleukin-10

health5 months ago•24 min saved

Immune ‘Off-Switch’ for Pain Found to Differ by Sex, Study Shows

A new Science Immunology study links IL-10–producing monocytes to an immune brake that dampens pain after injury. In mice, males had more IL-10–producing cells and recovered faster, with pain lasting longer when IL-10 or its receptor was blocked. Human data from the AURORA trauma study showed higher IL-10 levels at injury in men and lower subsequent pain, suggesting a biological basis for women’s longer-lasting pain. While not the sole pathway for all chronic pain, the findings point to immune signaling as a potential target, with ideas like skin-applied testosterone to modulate IL-10–positive monocytes under exploration (noting more research is needed).

via ZME Science|

#health #il-10 #immune-system

health6 months ago•3 min saved

Immune cells and hormones may explain why women's pain lasts longer

New research in mice and humans suggests that immune cells produce IL-10 to help resolve pain, and sex differences in this response—shaped by testosterone—may explain why women often recover more slowly from injury and have a higher risk of chronic pain. These findings point to therapies that boost the body's natural pain-resolution system rather than only blocking pain signals.

via The Conversation|

#gender-differences #health #il-10

science6 months ago•6 min saved

IL-10 Monocytes Explain Why Men Turn Off Pain Faster

A Michigan State University study shows IL-10–producing monocytes actively resolve inflammatory pain; higher testosterone in males boosts these cells, leading to faster pain relief, while females’ monocytes are less active and pain persists longer. This immune-driven mechanism suggests non-opioid treatments that enhance IL-10 signaling could prevent chronic pain.

via Neuroscience News|

#il-10 #monocytes #non-opioid-therapies

science7 months ago•4 min saved

Body's Natural Brake on Inflammation Identified, Hinting at Safer Treatments

A human study finds that fat-derived epoxy-oxylipins act as natural brakes on inflammation by preventing the buildup of intermediate monocytes. Blocking the enzyme soluble epoxide hydrolase (sEH) raises epoxy-oxylipin levels, speeding inflammation resolution and reducing harmful immune cell expansion, with the mechanism involving suppression of the p38 MAPK pathway. This points to safer, targeted therapies for chronic inflammatory diseases like arthritis and cardiovascular conditions.

via SciTechDaily|

#epoxy-oxylipins #inflammation #monocytes

health1 year ago•3 min saved

Severe COVID-19 Linked to Tumor Reduction in Early Study

A study suggests that severe COVID-19 infections may trigger immune responses that shrink cancer tumors. Research in mice showed that monocytes, a type of white blood cell, produced during severe COVID-19, can transform into cancer-fighting cells. These cells activate natural killer cells to attack tumors, offering a potential new therapeutic approach for advanced cancers. However, clinical trials are needed to confirm these effects in humans.

via Livescience.com|

#cancer #covid-19 #health

health3 years ago•4 min saved

Skipping Breakfast Weakens Immune System, Says Mount Sinai Study.

A study by the Icahn School of Medicine at Mount Sinai found that fasting, even for a short period, could negatively affect the immune system and increase the risk of heart disease. The study, which used mouse models, showed that skipping meals triggers a response in the brain that negatively affects immune cells, specifically monocytes. These cells travel through the body and play critical roles in fighting infections, heart disease, and cancer. Fasting causes monocytes to travel back to the bone marrow to hibernate, and production of new cells in the bone marrow diminishes. When food is reintroduced, the cells surge back into the bloodstream, leading to a heightened level of inflammation, making the body less resistant to fighting infection.

via SciTechDaily|

#brain #fasting #health

health3 years ago•6 min saved

Unraveling the Mysteries of Long COVID and its Impact on Health

Researchers at the University of Manchester have identified immune cells known as monocytes as a probable culprit for long Covid symptoms such as breathlessness. In a study of blood samples from Covid patients, the team found that monocytes with irregularities were linked to long Covid and lung injury. The scientists hypothesized that Covid increased CXCR6 in the monocytes, causing them to travel more readily toward the lungs and contribute to prolonged inflammation or damage. The next step for the scientists will be to try to modulate some of the pathways identified in monocytes using drugs to lower CXCR6 in animal models and seeing if symptoms improve.

via WIRED|

#breathlessness #health #immune-cells

health3 years ago•2 min saved

"Advancements in COVID research lead to potential life-saving treatments for high-risk patients."

Researchers from the University of Manchester have found a link between malfunctioning monocytes and specific symptoms of long COVID, such as fatigue and shortness of breath. This discovery could lead to the development of drug targets for treating long COVID. The study included 71 hospitalised patients with acute COVID-19 and 142 follow-up patients attending outpatient clinics months after hospital discharge. The researchers were able to distinguish long COVID patients with different symptoms from asymptomatic patients. This work provides an important first step towards finding treatments for those suffering from long COVID.

via Innovation Origins|

#covid-19 #health #immune-cells