Genetic Maps Reveal Why Two MS Models Aren’t Interchangeable

A Notre Dame team directly compares the CPZ and LPC MS demyelination models using single-cell RNA sequencing and human tissue, showing distinct genetic and cellular footprints and revealing that CPZ better models oligodendrocyte stress/repair while LPC captures immune responses; by matching model lesions to human MS data, the study provides a roadmap for choosing the right preclinical model to pursue remyelination therapies rather than only immune suppression.