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Myelin

All articles tagged with #myelin

Genetic Maps Reveal Why Two MS Models Aren’t Interchangeable
science7 days ago

Genetic Maps Reveal Why Two MS Models Aren’t Interchangeable

A Notre Dame team directly compares the CPZ and LPC MS demyelination models using single-cell RNA sequencing and human tissue, showing distinct genetic and cellular footprints and revealing that CPZ better models oligodendrocyte stress/repair while LPC captures immune responses; by matching model lesions to human MS data, the study provides a roadmap for choosing the right preclinical model to pursue remyelination therapies rather than only immune suppression.

via Neuroscience News|
#multiple-sclerosis#myelin#neuroscience
Glucose Signals Turn On the Brain’s Myelin Growth Timeline
science26 days ago

Glucose Signals Turn On the Brain’s Myelin Growth Timeline

Scientists mapped glucose in the developing brain and found that high local glucose drives oligodendrocyte progenitor cell (OPC) proliferation via nuclear acetyl-CoA produced by the enzyme ACLY, while lower glucose cues these cells to mature into myelin-forming oligodendrocytes. In ACLY-deficient mice, ketogenic diets can partially rescue myelin deficits by providing an alternative fuel source. This reveals a metabolic switch that times and regionalizes myelin formation during a critical late-gestation window (roughly 32–40 weeks in humans), with implications for premature white-matter injury and potential myelin-repair strategies in diseases like multiple sclerosis.

via Neuroscience News|
#acly#brain-development#metabolism
Sleep Deprivation Slows Brain Signals by Thinning Myelin, New Study Finds
health1 month ago

Sleep Deprivation Slows Brain Signals by Thinning Myelin, New Study Finds

A study combining MRI data from 185 sleep-deprived adults with animal experiments shows sleep loss thins brain myelin and disrupts cholesterol delivery, slowing interhemispheric signal transmission and leading to attention, memory, and motor impairments. Restoring myelin-related processes in animals by boosting cholesterol suggests a biological target for intervention. To protect brain health when sleep is limited, aim for 7–9 hours of sleep, consume healthy fats to support myelin, take short naps, optimize the sleep environment, and maintain regular exercise.

via Yahoo|
#brain#brain-imaging#health
High-altitude yak gene hints at a new MS nerve repair path
health1 month ago

High-altitude yak gene hints at a new MS nerve repair path

A study suggests a yak-adapted gene called Restat, which boosts a vitamin A–related molecule (ATDR), may help repair the myelin sheath around nerves. In mice engineered with the mutation and exposed to low-oxygen conditions, researchers saw thicker, healthier myelin and faster repair after damage, offering a potential new avenue for treating multiple sclerosis and possibly other nerve-damage conditions.

via New York Post|
#atdr#health#multiple-sclerosis
Xi–αNET Connects Brain Wiring to EEG Rhythms Across the Lifespan
science1 month ago

Xi–αNET Connects Brain Wiring to EEG Rhythms Across the Lifespan

A multinational study introduces Xi–αNET, a generative model that links EEG signals (the background ξ and alpha rhythms) to the brain’s physical wiring and axonal conduction delays across ages 5–100 using the HarMNqEEG dataset. The findings show alpha frequency scales with myelin-driven conduction speed, producing a U-shaped trajectory of conduction delays with age and slower rhythms in older adults; the model also detects Parkinson’s-related alpha slowing, highlighting potential EEG-based brain-health benchmarks and early disease flagging via normative charts.

via Neuroscience News|
#aging#eeg#myelin
Mountain Gene Triggers Innate Nerve Repair Pathway for Myelin Recovery
science2 months ago

Mountain Gene Triggers Innate Nerve Repair Pathway for Myelin Recovery

A gain-of-function mutation in the high-altitude Retsat gene helps restore myelin and promote nerve repair in mice by boosting vitamin A–derived metabolites that support oligodendrocyte maturation. The study, published in Neuron (March 13, 2026), suggests a natural, body-made pathway to treat myelin-related conditions such as multiple sclerosis and cerebral palsy, potentially reducing the need for immune-targeting drugs by enhancing innate regenerative processes.

via SciTechDaily|
#high-altitude-adaptation#myelin#neural-repair
Anti-Aging Drug Duo Triggers Brain Myelin Loss in Mice, Study Finds
neuroscience2 months ago

Anti-Aging Drug Duo Triggers Brain Myelin Loss in Mice, Study Finds

University of Connecticut researchers report that the anti-aging drug combination dasatinib and quercetin (D+Q) causes significant myelin loss and corpus callosum damage in mice, with younger animals affected more. The oligodendrocytes shift to a less mature, energy-stressed state, suggesting safety concerns for preventive use and offering new clues for understanding multiple sclerosis.

via SciTechDaily|
#anti-aging#brain#multiple-sclerosis
Psychedelics Remodel Brain Myelin for Lasting PTSD Recovery
science2 months ago

Psychedelics Remodel Brain Myelin for Lasting PTSD Recovery

A rat study shows psilocybin and MDMA trigger adaptive myelination, repairing the brain’s insulation (myelin) in fear circuits and producing long-lasting reductions in anxiety-like behavior; blocking myelin repair abolishes the benefits, indicating myelin remodeling is a key mechanism for durable psychedelic-assisted PTSD therapy and should complement, not replace, psychotherapy.

via Neuroscience News|
#myelin#neuroplasticity#oligodendrocytes
Sleep Deprivation Thins Brain Myelin and Slows Signals, Study Finds
science3 months ago

Sleep Deprivation Thins Brain Myelin and Slows Signals, Study Finds

New research links sleep loss to damage in oligodendrocytes that insulate neurons, thinning myelin and slowing brain signaling in rats, while human MRI data show reduced white-matter integrity with poorer sleep. In rats, sleep deprivation disrupted cholesterol handling by oligodendrocytes and slowed inter-regional communications, but restoring cholesterol transfer with cyclodextrin improved function, suggesting a potential target for mitigating sleep-loss effects, though human confirmation is needed.

via ScienceAlert|
#brain#myelin#neuroscience
Myelin Loss Disrupts Brain Signal Processing and Thought
science5 months ago

Myelin Loss Disrupts Brain Signal Processing and Thought

Scientists discovered that losing a small, critical segment of myelin disrupts brain communication by impairing the transmission of signals between the cortex and thalamus, which can lead to cognitive issues similar to those seen in Multiple Sclerosis. The study highlights the importance of myelin in maintaining the structure of neural information transfer and suggests potential avenues for future recovery strategies.

via SciTechDaily|
#brain#cognition#ms
Signaling Molecules Hinder Myelin-Producing Brain Cell Growth
health11 months ago

Signaling Molecules Hinder Myelin-Producing Brain Cell Growth

A cell study shows that pro-inflammatory molecules like TNF-alpha and interferon gamma impair the growth of myelin-producing cells in the brain, potentially contributing to multiple sclerosis by hindering myelin repair. The research suggests that promoting oligodendrocyte development while preventing astrocyte-like transformation could be a promising therapeutic strategy for MS.

via Multiple Sclerosis News Today|
#health#inflammation#multiple-sclerosis