Gut Microbes Employ Protein-Delivery Syringes to Rewire Human Immunity
TL;DR
Researchers showed that common gut bacteria have type III secretion systems that inject proteins into human cells, altering immune signaling (including NF-κB and cytokine responses); these interactions are enriched in Crohn’s disease microbiomes, suggesting commensals can actively shape inflammation and may help explain microbiome–disease links while guiding future therapies.
Topics:healthscience#bacterial-effector-proteins#crohns-disease#gut-microbiome#immune-modulation#science#type-iii-secretion-system
- Scientists Discover Gut Bacteria Can Inject Proteins Into Human Cells SciTechDaily
- Effector–host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation Nature
- Gut bacteria use proteins to communicate directly with our cells Earth.com
- How gut bacteria control immune responses Phys.org
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