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Crohns Disease

All articles tagged with #crohns disease

Single-cell atlas maps Crohn’s disease drivers in ileal tissue
science25 days ago

Single-cell atlas maps Crohn’s disease drivers in ileal tissue

Researchers generated IBDverse, a 1.1‑million‑cell scRNA‑seq atlas of terminal ileal biopsies from 111 Crohn’s disease patients and 232 controls, using discovery and replication cohorts to identify robust cell-type signatures. They map 57 cell clusters across epithelial, immune and mesenchymal compartments, find IFN‑driven MHC‑I upregulation in epithelial cells (persisting in progenitors after inflammation resolves), and identify ITGA4+ macrophages as key inflammatory drivers with enriched JAK–STAT signaling and IL‑6/IL‑12/IL‑23 production. Heritability analyses link inflammatory monocytes and macrophages to CD risk, outlining a cellular–molecular framework with therapeutic implications; data and code are publicly available.

via Nature|
#crohns-disease#epithelial-cells#jak-stat-signaling
Redhead Genes Show Immune Perks, But Higher Autoimmune Risks
science2 months ago

Redhead Genes Show Immune Perks, But Higher Autoimmune Risks

A Harvard Medical School study of ancient DNA from about 16,000 people over 10,000 years finds that the genetic variants behind red hair and fair skin may confer immune benefits (including potential HIV resistance and leprosy resistance) and lower arthritis risk, but also raise the risk of Crohn's disease and celiac disease due to gluten sensitivity, suggesting a trade‑off shaped by ancient selection and the spread of wheat farming.

via Yahoo|
#celiac-disease#crohns-disease#genetics
Redhead Genomics: Immune Perks But Gluten-Linked Health Tradeoffs
science2 months ago

Redhead Genomics: Immune Perks But Gluten-Linked Health Tradeoffs

Harvard Medical School researchers analyzed 10,000 years of DNA from about 16,000 people and found that the genetic variants behind red hair and fair skin were favored by natural selection, with potential immune benefits (including HIV resistance and leprosy resistance) and lower risk of certain conditions, but these same genes may raise the risk of gluten-related autoimmune diseases such as Crohn’s disease and celiac disease, possibly linked to the advent of wheat farming; vitamin D production advantages were noted in earlier work.

via Yahoo News Canada|
#celiac-disease#crohns-disease#genetics
ER dismissal, then rectal cancer: a Toronto model’s urgent cancer journey
health4 months ago

ER dismissal, then rectal cancer: a Toronto model’s urgent cancer journey

Toronto model Jess Grossman, who lives with an ostomy after childhood Crohn’s disease and colon removal, says ER staff brushed off her persistent pelvic pain as endometriosis until a CT scan raised flags. After a biopsy, she was diagnosed with rectal cancer four weeks from the first symptoms and is undergoing eight rounds of chemotherapy (16 weeks total) to shrink the tumor before potential surgery to remove the rectal stump. She documents her journey online to raise awareness about colorectal cancer and the importance of early detection.

via Yahoo Lifestyle Canada|
#chemotherapy#crohns-disease#early-detection
When Early Signs Are Overlooked: One Woman’s Crohn’s Journey and Ostomy Advocacy
health4 months ago

When Early Signs Are Overlooked: One Woman’s Crohn’s Journey and Ostomy Advocacy

Paula Sojo’s viral TikTok recounts years of dismissed symptoms before a severe Crohn’s diagnosis at 18, followed by surgeries including a proctocolectomy and a permanent ostomy; now in remission and using her platform and her Osto•me Fashion brand to raise awareness, empower ostomy wearers, and push for earlier detection in others.

via AOL.com|
#crohns-disease#health#misdiagnosis
Stool biomarkers and meat intake may forewarn IBD flares, study suggests
health4 months ago

Stool biomarkers and meat intake may forewarn IBD flares, study suggests

A large UK study (PREdiCCt) of over 2,600 people with inflammatory bowel disease found that higher baseline fecal calprotectin, a noninvasive stool marker of gut inflammation, strongly predicted future flares even when patients were symptom-free—UC patients with elevated calprotectin faced about a 34% objective flare risk within 2 years vs ~11% with low levels. Habitual meat intake was linked to nearly double the risk of ulcerative colitis flares, while other dietary factors showed no consistent associations; there was no such meat-flare link for Crohn’s disease. The results point to a potential for biomarker- and diet‑guided, personalized IBD management, using stool tests plus dietary data to forecast relapses months ahead. However, the study is observational and cannot prove causation, and local validation may be needed before widespread adoption.

via AOL.com|
#crohns-disease#fecal-calprotectin#health
Gut Microbes Employ Protein-Delivery Syringes to Rewire Human Immunity
science5 months ago

Gut Microbes Employ Protein-Delivery Syringes to Rewire Human Immunity

Researchers showed that common gut bacteria have type III secretion systems that inject proteins into human cells, altering immune signaling (including NF-κB and cytokine responses); these interactions are enriched in Crohn’s disease microbiomes, suggesting commensals can actively shape inflammation and may help explain microbiome–disease links while guiding future therapies.

via SciTechDaily|
#bacterial-effector-proteins#crohns-disease#gut-microbiome