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Inflammation Reprograms Brain Stem Cells to Halt Neurogenesis

1 min read
Source: Neuroscience News
Inflammation Reprograms Brain Stem Cells to Halt Neurogenesis
Photo: Neuroscience News
TL;DR

A King’s College London study shows chronic TNF-α–driven inflammation stops neurogenesis in the hippocampus by reprogramming neural stem cells into an immune-alert state that recruits inflammatory T cells; blocking Type I interferon signaling with an antibody reverses the effect, restoring neuron production and suggesting therapy avenues for brain fog and cognitive decline.

Topics:healthscience#hippocampus#inflammation#neurogenesis#science#tnf-a#type-i-interferon
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  1. Inflammation Forces Brain Stem Cells to Halt Neurogenesis  Neuroscience News
  2. Mechanism linking chronic inflammation to reduced brain regeneration identified  Medical Xpress
  3. TNF-α induces type I IFN signalling to suppress neurogenesis and recruit T cells  Nature

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