All articles tagged with #type i interferon
A King’s College London study shows chronic TNF-α–driven inflammation stops neurogenesis in the hippocampus by reprogramming neural stem cells into an immune-alert state that recruits inflammatory T cells; blocking Type I interferon signaling with an antibody reverses the effect, restoring neuron production and suggesting therapy avenues for brain fog and cognitive decline.
Loss-of-function mutations in the PLD4 gene are linked to systemic lupus erythematosus (SLE), with affected patients showing immune dysregulation characterized by overactivation of the type I interferon pathway, impaired exonuclease activity of PLD4, and increased activation of TLR7/9 pathways, leading to autoimmune manifestations. Mouse models confirm the role of PLD4 deficiency in autoimmunity, and JAK inhibitors like baricitinib show therapeutic potential by reducing inflammation and autoantibody levels.