Liver Signal Bypasses the Hypothalamus to Rewrite Diet and Metabolism
TL;DR Summary
A study identifies a specific hindbrain neuron population (NTS-KLB) that directly responds to the liver hormone FGF21 to orchestrate changes in food intake, food choice, and energy expenditure during dietary protein restriction, challenging the idea that metabolism is controlled mainly by the hypothalamus and suggesting targeted brain circuits could improve FGF21-based obesity and diabetes therapies.
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