Tag

Hindbrain

All articles tagged with #hindbrain

science20 days ago•9 min saved

New Study Reveals Brain Develops from Two Distinct Progenitor Lines, Not One

A study published in Nature Neuroscience on September 18, 2026, challenges the traditional view that the human brain develops from a single progenitor cell. Researchers from Stanford Medicine found that the forebrain/midbrain and hindbrain arise from two separate, parallel neural ectoderm populations during embryonic gastrulation. This finding explains why hindbrain neurons have been difficult to cultivate in labs and enables the first successful derivation of hindbrain motor neurons from human pluripotent stem cells, offering new avenues for studying diseases like ALS and SMA.

via Ars Technica|

#developmental-biology #hindbrain #neuroscience

science5 months ago•6 min saved

Liver Signal Bypasses the Hypothalamus to Rewrite Diet and Metabolism

A study identifies a specific hindbrain neuron population (NTS-KLB) that directly responds to the liver hormone FGF21 to orchestrate changes in food intake, food choice, and energy expenditure during dietary protein restriction, challenging the idea that metabolism is controlled mainly by the hypothalamus and suggesting targeted brain circuits could improve FGF21-based obesity and diabetes therapies.

via Neuroscience News|

#energy-expenditure #fgf21 #hindbrain

health5 months ago•6 min saved

FGF21 Signals to Hindbrain May Boost Metabolic Weight Loss

University of Oklahoma researchers identify FGF21 as a hormone that signals the hindbrain—the same region GLP-1 obesity drugs target—potentially increasing metabolic rate and promoting weight loss in mice. While promising, the findings are preclinical, and safety concerns (digestive issues, bone loss) and human relevance remain unresolved; future therapies may pair FGF21 pathways to treat obesity and related fatty liver disease (MASH).

via Fox News|

#fgf21 #glp-1 #health

science6 months ago•6 min saved

Natural Hormone FGF21 Rewires the Brain to Fight Obesity

Researchers found that the hormone FGF21 acts in the hindbrain (nucleus of the solitary tract and area postrema) to regulate metabolism and reduce body weight, signaling a shared yet distinct pathway from GLP-1 drugs. The work, published in Cell Reports, suggests a specific brain circuit could be targeted for obesity and MASH therapies, though current FGF21 analogs can cause GI issues and bone loss, prompting hopes for safer, more precise treatments.

via SciTechDaily|

#fgf21 #glp-1 #hindbrain

science2 years ago•4 min saved

"Sea Lamprey: Surprising Similarities in Brain Development with Humans"

A study from the Stowers Institute for Medical Research reveals that the hindbrain of sea lampreys and humans is constructed using a remarkably similar molecular and genetic toolkit, shedding light on the evolution of vertebrate traits. The research, published in Nature Communications, identifies a common molecular cue, retinoic acid, involved in guiding hindbrain patterning in sea lampreys, suggesting that this process is ancestral to all vertebrates. The findings challenge previous assumptions about the differences between jawless and jawed vertebrates, highlighting the close evolutionary relationship between sea lampreys and humans.

via EurekAlert|

#evolution #genetics #hindbrain