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Energy Expenditure

All articles tagged with #energy expenditure

Experimental fat-burner TOFA triggers fat loss by boosting energy use in obese mice
science3 days ago

Experimental fat-burner TOFA triggers fat loss by boosting energy use in obese mice

UC Berkeley researchers report that the experimental compound TOFA (5-tetradecyloxy-2-furoic acid) increased whole-body energy expenditure by up to 18% and produced about 18% weight loss in obese male mice on a high-fat diet over four weeks, mainly from fat while preserving lean mass; food intake and activity were unchanged. TOFA appears to slow fat creation and boost fat burning, though exact cellular mechanisms are unclear. Lower-dose TOFA combined with GLP-1 drugs semaglutide or tirzepatide yielded greater weight loss than either alone, suggesting potential synergy. The work is in mice, TOFA has not been tested in humans, and safety/dosing are unknown; further toxicology and animal studies precede any human trials. Authors are co-founders of ReRx Therapeutics.

via ScienceAlert|
#energy-expenditure#fat-metabolism#mice
Old ACC inhibitor TOFA drives fat burning while preserving muscle in mice
health-and-medicine6 days ago

Old ACC inhibitor TOFA drives fat burning while preserving muscle in mice

UC Berkeley researchers report that TOFA, an old ACC inhibitor, lowers lipid production and activates fat-burning energy pathways in obese mice, increasing energy use by up to 18% and reducing fat while preserving lean mass; it also improves insulin sensitivity and triglycerides and works additively with GLP-1 obesity drugs, though safety in humans remains untested and researchers are pursuing clinical development.

via Science Daily|
#energy-expenditure#glp-1#health-and-medicine
Calorie Readouts on Apple Watch Remain Educated Guesses, Not Exact Measurements
technology1 month ago

Calorie Readouts on Apple Watch Remain Educated Guesses, Not Exact Measurements

New analysis finds Apple Watch calorie readings are educated guesses, not precise measurements: wearables can track heart rate, but energy expenditure is estimated from proxies like movement and heart rate, leading to sizable errors (Stanford 2024: average ~27% off, some devices up to 93% off); a Nature study also notes accuracy degrades with factors like multiple sensors and skin tone. Providing height and weight may improve estimates, but true calorie burn remains highly variable, so treat these numbers as estimates rather than exact facts.

via Engadget|
#apple-watch#calorie-tracking#energy-expenditure
Liver Signal Bypasses the Hypothalamus to Rewrite Diet and Metabolism
science4 months ago

Liver Signal Bypasses the Hypothalamus to Rewrite Diet and Metabolism

A study identifies a specific hindbrain neuron population (NTS-KLB) that directly responds to the liver hormone FGF21 to orchestrate changes in food intake, food choice, and energy expenditure during dietary protein restriction, challenging the idea that metabolism is controlled mainly by the hypothalamus and suggesting targeted brain circuits could improve FGF21-based obesity and diabetes therapies.

via Neuroscience News|
#energy-expenditure#fgf21#hindbrain
From Storage to Heat: Harnessing Fat's Energy-Burning Power for Weight Loss
science-tech5 months ago

From Storage to Heat: Harnessing Fat's Energy-Burning Power for Weight Loss

Fat is not just storage: brown fat burns calories to generate heat, beige fat can arise within white fat, and both offer targets for obesity therapies. The next generation of treatments may combine GLP-1–based appetite suppression with methods to boost energy expenditure across fat, muscle, and liver, aiming for more durable weight loss while avoiding hunger-driven compensation. This reframes fat as a dynamic metabolic organ and points to a multi-tissue, precision approach to energy balance.

via The Conversation|
#adipose-tissue#beige-fat#brown-fat
Epaulette Shark Defies Reproduction Energy Expectations
science7 months ago

Epaulette Shark Defies Reproduction Energy Expectations

A study of the epaulette shark finds reproduction does not trigger a rise in metabolic energy use, challenging the idea that shark reproduction is highly energy-intensive. By monitoring oxygen uptake and hormones during egg-laying, researchers observed a flat energy demand, suggesting sharks have evolved efficient reproductive physiology. This adaptation could help sharks persist as oceans warm, with positive implications for coral reef health.

via Yahoo News Canada|
#climate-stress#energy-expenditure#epaulette-shark
Walking Sharks Reproduce Without Extra Energy, Study Finds
science7 months ago

Walking Sharks Reproduce Without Extra Energy, Study Finds

Australian scientists studying epaulette (walking) sharks found that egg production uses no extra energy, challenging the idea that reproduction is always energetically costly. The flat energy demand suggests a unique adaptation that may help these sharks reproduce under environmental stress, with implications for shark populations and reef health amid warming oceans.

via Indian Defence Review|
#energy-expenditure#epaulette-sharks#reef-ecosystems
Physical Activity Boosts Daily Energy Expenditure
health10 months ago

Physical Activity Boosts Daily Energy Expenditure

A study published in PNAS shows that increased physical activity leads to higher daily calorie burn without the body compensating by reducing energy use elsewhere, supporting the idea that exercise adds to overall energy expenditure rather than redistributing it. The research involved measuring energy use in participants with varying activity levels and found that more active individuals burn more calories overall, with less time spent inactive, although further research is needed to understand potential energy compensation under different conditions.

via Virginia Tech News|
#calorie-burn#energy-budget#energy-expenditure