Tag

Energy Expenditure

All articles tagged with #energy expenditure

health1 month ago•4 min saved

TOFA boosts fat burning without appetite loss, preserves muscle in obese mice

UC Berkeley researchers identify oral TOFA as a weight-loss candidate that increases energy expenditure in obese mice (≈18% weight loss) without reducing appetite or lean mass, by blocking lipid production and activating fat-burning genes. It also reduced liver fat/inflammation in mouse models and showed enhanced effects when combined with drugs like semaglutide or tirzepatide, but human safety, dosing, and long-term effects remain unknown; results are limited to mice to date.

via AOL.com|

#energy-expenditure #health #muscle-preservation

health1 month ago•7 min saved

Oral TOFA boosts fat burning and may preserve muscle in weight loss

Researchers at UC Berkeley identified TOFA, an oral compound that reduced body weight in obese mice by about 18% by increasing energy expenditure rather than suppressing appetite, and it preserved lean mass; when paired with GLP-1 drugs such as semaglutide or tirzepatide, it produced greater weight loss and improved metabolic markers; TOFA also showed liver benefits in mouse models of fatty liver disease, without raising triglycerides. The effects in humans are unknown, the study involved only male mice, and questions remain about dosing, safety, and long-term risks before any human use.

via foxnews.com|

#energy-expenditure #health #mice-study

science1 month ago•6 min saved

Experimental fat-burner TOFA triggers fat loss by boosting energy use in obese mice

UC Berkeley researchers report that the experimental compound TOFA (5-tetradecyloxy-2-furoic acid) increased whole-body energy expenditure by up to 18% and produced about 18% weight loss in obese male mice on a high-fat diet over four weeks, mainly from fat while preserving lean mass; food intake and activity were unchanged. TOFA appears to slow fat creation and boost fat burning, though exact cellular mechanisms are unclear. Lower-dose TOFA combined with GLP-1 drugs semaglutide or tirzepatide yielded greater weight loss than either alone, suggesting potential synergy. The work is in mice, TOFA has not been tested in humans, and safety/dosing are unknown; further toxicology and animal studies precede any human trials. Authors are co-founders of ReRx Therapeutics.

via ScienceAlert|

#energy-expenditure #fat-metabolism #mice

health-and-medicine1 month ago•7 min saved

Old ACC inhibitor TOFA drives fat burning while preserving muscle in mice

UC Berkeley researchers report that TOFA, an old ACC inhibitor, lowers lipid production and activates fat-burning energy pathways in obese mice, increasing energy use by up to 18% and reducing fat while preserving lean mass; it also improves insulin sensitivity and triglycerides and works additively with GLP-1 obesity drugs, though safety in humans remains untested and researchers are pursuing clinical development.

via Science Daily|

#energy-expenditure #glp-1 #health-and-medicine

technology2 months ago•4 min saved

Calorie Readouts on Apple Watch Remain Educated Guesses, Not Exact Measurements

New analysis finds Apple Watch calorie readings are educated guesses, not precise measurements: wearables can track heart rate, but energy expenditure is estimated from proxies like movement and heart rate, leading to sizable errors (Stanford 2024: average ~27% off, some devices up to 93% off); a Nature study also notes accuracy degrades with factors like multiple sensors and skin tone. Providing height and weight may improve estimates, but true calorie burn remains highly variable, so treat these numbers as estimates rather than exact facts.

via Engadget|

#apple-watch #calorie-tracking #energy-expenditure

science5 months ago•6 min saved

Liver Signal Bypasses the Hypothalamus to Rewrite Diet and Metabolism

A study identifies a specific hindbrain neuron population (NTS-KLB) that directly responds to the liver hormone FGF21 to orchestrate changes in food intake, food choice, and energy expenditure during dietary protein restriction, challenging the idea that metabolism is controlled mainly by the hypothalamus and suggesting targeted brain circuits could improve FGF21-based obesity and diabetes therapies.

via Neuroscience News|

#energy-expenditure #fgf21 #hindbrain

science-tech7 months ago•12 min saved

From Storage to Heat: Harnessing Fat's Energy-Burning Power for Weight Loss

Fat is not just storage: brown fat burns calories to generate heat, beige fat can arise within white fat, and both offer targets for obesity therapies. The next generation of treatments may combine GLP-1–based appetite suppression with methods to boost energy expenditure across fat, muscle, and liver, aiming for more durable weight loss while avoiding hunger-driven compensation. This reframes fat as a dynamic metabolic organ and points to a multi-tissue, precision approach to energy balance.

via The Conversation|

#adipose-tissue #beige-fat #brown-fat

science8 months ago•34 min saved

Epaulette Shark Defies Reproduction Energy Expectations

A study of the epaulette shark finds reproduction does not trigger a rise in metabolic energy use, challenging the idea that shark reproduction is highly energy-intensive. By monitoring oxygen uptake and hormones during egg-laying, researchers observed a flat energy demand, suggesting sharks have evolved efficient reproductive physiology. This adaptation could help sharks persist as oceans warm, with positive implications for coral reef health.

via Yahoo News Canada|

#climate-stress #energy-expenditure #epaulette-shark

science8 months ago•4 min saved

Walking Sharks Reproduce Without Extra Energy, Study Finds

Australian scientists studying epaulette (walking) sharks found that egg production uses no extra energy, challenging the idea that reproduction is always energetically costly. The flat energy demand suggests a unique adaptation that may help these sharks reproduce under environmental stress, with implications for shark populations and reef health amid warming oceans.

via Indian Defence Review|

#energy-expenditure #epaulette-sharks #reef-ecosystems

science11 months ago•4 min saved

Scientists Discover the Fundamental Metabolic Limit of Human Endurance

A study finds that humans have a metabolic ceiling at about 2.5 times their basal metabolic rate, which even elite endurance athletes cannot sustainably surpass, highlighting the biological limits of human endurance.

via SciTechDaily|

#biological-limits #energy-expenditure #human-endurance

science11 months ago•3 min saved

Physical Activity Boosts Daily Energy Expenditure, Study Finds

A study published in PNAS found that increased physical activity leads to higher daily calorie burn without the body compensating by reducing energy use elsewhere, supporting an additive model of energy expenditure.

via Medical Xpress|

#calorie-burn #energy-budget #energy-expenditure

health11 months ago•3 min saved

Physical Activity Boosts Daily Energy Expenditure

A study published in PNAS shows that increased physical activity leads to higher daily calorie burn without the body compensating by reducing energy use elsewhere, supporting the idea that exercise adds to overall energy expenditure rather than redistributing it. The research involved measuring energy use in participants with varying activity levels and found that more active individuals burn more calories overall, with less time spent inactive, although further research is needed to understand potential energy compensation under different conditions.

via Virginia Tech News|

#calorie-burn #energy-budget #energy-expenditure

science11 months ago•3 min saved

The Fundamental Metabolic Limit of Human Endurance

A study finds that even elite athletes have a 'metabolic ceiling' at about 2.4 times their basal metabolic rate over long periods, limiting how much energy they can expend, with increased activity leading to unconscious reductions in other energy uses.

via Nature|

#athletes #basal-metabolic-rate #energy-expenditure

health1 year ago•92 min saved

Diet Over Exercise: New Study Explains Obesity Trends

A new study suggests that diet plays a more significant role than lack of exercise in obesity, as energy expenditure differences across economic groups do not account for obesity variations, emphasizing the importance of dietary intake over physical activity for weight management.

via Hacker News|

#caloric-intake #diet #energy-expenditure

health1 year ago•7 min saved

New Study Reveals Diet, Not Exercise, as Main Cause of US Obesity

A global study shows that obesity in developed countries is driven more by high intake of ultra-processed foods than by reduced physical activity, despite higher calorie burn in these populations, challenging common assumptions about inactivity being the main cause of obesity.

via Study Finds|

#diet #energy-expenditure #health