Longevity Metabolite Reawakens Memory in Alzheimer’s Models

A team at the National University of Singapore found that the natural metabolite calcium alpha-ketoglutarate (CaAKG), linked to healthy aging, improves neuron signaling and associative memory in Alzheimer’s mouse models by restoring long-term potentiation and boosting autophagy, suggesting aging biology pathways could be targeted to slow cognitive decline.