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Synaptic Plasticity

All articles tagged with #synaptic plasticity

Decoding Ketamine: Low-dose drug combos aim for rapid, safer antidepressant effects
science28 days ago

Decoding Ketamine: Low-dose drug combos aim for rapid, safer antidepressant effects

Two studies reveal how ketamine triggers rapid antidepressant effects by briefly silencing interneuron brakes in the prefrontal cortex via mu-opioid receptors, and show that a low-dose three-drug combo can replicate this benefit with fewer side effects; longer-lasting relief depends on TrkB and mGluR5 receptor cross-talk driven by BDNF, which strengthens and stabilizes synapses. Researchers plan accelerated clinical trials using safe, existing drugs to translate these findings into patient treatments.

via Neuroscience News|
#clinical-trials#depression#ketamine
Longevity Metabolite Reawakens Memory in Alzheimer’s Models
science4 months ago

Longevity Metabolite Reawakens Memory in Alzheimer’s Models

A team at the National University of Singapore found that the natural metabolite calcium alpha-ketoglutarate (CaAKG), linked to healthy aging, improves neuron signaling and associative memory in Alzheimer’s mouse models by restoring long-term potentiation and boosting autophagy, suggesting aging biology pathways could be targeted to slow cognitive decline.

via SciTechDaily|
#aging#alzheimers-disease#calcium-alpha-ketoglutarate
"Brain's Storage Capacity Far Greater Than Previously Believed"
neuroscience2 years ago

"Brain's Storage Capacity Far Greater Than Previously Believed"

Researchers at the Salk Institute have discovered that synapses in the brain can store 10 times more information than previously thought, using a new method based on information theory. This breakthrough enhances understanding of learning, memory, and brain disorders, potentially advancing research on conditions like Alzheimer's disease.

via Neuroscience News|
#information-storage#learning-and-memory#neurodegenerative-disorders
"Unlocking Brain Storage: Measuring Synaptic Information Capacity"
neuroscience2 years ago

"Unlocking Brain Storage: Measuring Synaptic Information Capacity"

Researchers at the Salk Institute have developed a new method using information theory to measure synaptic strength, plasticity, and information storage in the brain, revealing that synapses can store 10 times more information than previously thought. This breakthrough could significantly advance our understanding of learning, memory, and neurological diseases.

via Medical Xpress|
#brain-storage#information-theory#learning-and-memory
"Unlocking Neurogenesis: The Crucial Role of Mitochondria in Brain Repair"
neuroscience2 years ago

"Unlocking Neurogenesis: The Crucial Role of Mitochondria in Brain Repair"

Researchers have discovered that mitochondrial fusion dynamics play a crucial role in the maturation of adult-born neurons in the brain, supporting synaptic plasticity in the adult hippocampus. This insight could lead to new strategies for treating neurological disorders like Alzheimer's and Parkinson's by targeting mitochondrial dynamics to enhance brain repair and cognitive functions. The study suggests that altered neurogenesis is linked to these disorders and that understanding the role of mitochondrial fusion in controlling synaptic function could guide specific interventions to restore neuronal plasticity and cognitive functions in disease.

via Neuroscience News|
#brain-repair#cognitive-function#mitochondria
"Cracking the Brain's Memory Code: A Novel Neural Model Unveiled"
neuroscience2 years ago

"Cracking the Brain's Memory Code: A Novel Neural Model Unveiled"

Researchers have developed a new neural model that sheds light on the intricate mechanisms of synaptic plasticity, emphasizing the crucial role of interactions among adjacent synaptic connections in facilitating rapid learning and the consolidation of long-term memories. This breakthrough offers a comprehensive understanding of synaptic co-dependency, challenging the traditional view of isolated synaptic changes and providing novel insights into the dynamics and optimization of neural networks in the brain at the microscale.

via Neuroscience News|
#brain-plasticity#learning#memory-formation
"Israeli Scientists' Mushroom Extract Surpasses Synthetic Psilocybin in Psychiatric Therapy"
neuroscience2 years ago

"Israeli Scientists' Mushroom Extract Surpasses Synthetic Psilocybin in Psychiatric Therapy"

A study led by researchers at the Hebrew University of Jerusalem suggests that mushroom extract containing psilocybin may have a more potent and enduring impact on synaptic plasticity compared to chemically synthesized psilocybin. The research, focusing on synaptic plasticity in mice, reveals promising insights into the potential therapeutic benefits of natural psychedelic compounds in addressing psychiatric disorders. The study's findings open up new possibilities for the therapeutic use of natural psychedelic compounds, providing hope for those who have found little relief in conventional psychiatric treatments. Controlled mushroom cultivation offers a promising approach to replicate extracts for medicinal use, highlighting the feasibility of incorporating them into Western medicine.

via Neuroscience News|
#mushroom-extract#natural-compounds#neuroscience
"Brain Receptor Linking Anxiety and Testosterone Discovered in New Study"
neuroscience2 years ago

"Brain Receptor Linking Anxiety and Testosterone Discovered in New Study"

A study led by Prof. Shira Knafo at Ben-Gurion University has revealed a significant link between anxiety disorders and the brain receptor TACR3, as well as testosterone. The research found that rodents with high anxiety had low TACR3 levels in the hippocampus, and that testosterone deficiency-related anxiety could be addressed by targeting TACR3. The study employed innovative tools to advance understanding of synaptic plasticity and its role in anxiety, offering new therapeutic possibilities for treating anxiety disorders, especially in individuals with hypogonadism.

via Neuroscience News|
#anxiety-disorders#ben-gurion-university#neuroscience
health2 years ago

"Neurological Link Between Anxiety and Testosterone Uncovered in Israeli Study"

A new study from Ben-Gurion University of the Negev has found a potential neurological link between anxiety disorders and the TACR3 receptor in the hippocampus, particularly in male rodents with high anxiety levels. The research suggests that deficiencies in TACR3 may be associated with low testosterone levels and anxiety, and that these deficiencies can be rectified through testosterone administration, offering hope for new approaches to managing anxiety related to testosterone deficiency.

via The Jerusalem Post|
#anxiety-disorders#health#neurological-research