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Metformin’s Brain Link: New Pathway Behind a 60-Year-Old Diabetes Drug

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Source: ScienceAlert
Metformin’s Brain Link: New Pathway Behind a 60-Year-Old Diabetes Drug
Photo: ScienceAlert
TL;DR Summary

A Science Advances study in mice shows metformin lowers glucose via brain Rap1 signaling in the ventromedial hypothalamus, not just liver or gut; deleting Rap1 in this brain region abolishes metformin’s effect, while direct brain administration also lowers glucose, suggesting brain-targeted mechanisms could unlock new diabetes therapies and possibly aging benefits.

Topics:health#brain#diabetes#hypothalamus#metformin#rap1#science
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  1. Diabetes Drug Used For More Than 60 Years Found to Unexpectedly Affect The Brain  ScienceAlert
  2. After 60 years, scientists uncover metformin’s hidden brain effects  ScienceDaily
  3. Study finds metformin lowers blood sugar through brain pathway  سانا
  4. Diabetes News: Metformin’s Brain Action  Daily Kos

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