Mice study warns anti-aging drug duo may harm brain myelin

A University of Connecticut study found that the senolytic combo dasatinib and quercetin (D+Q) damaged brain myelin in mice, particularly in the corpus callosum, by changing oligodendrocyte cells and limiting myelin production. The small animal results raise safety concerns for D+Q in ongoing trials and off-label use, underscoring the need for further CNS-focused testing before widespread adoption.