Tag

Senolytics

All articles tagged with #senolytics

science2 days ago•4 min saved

Not All Aging 'Zombie' Cells Are Bad: Precision Therapies Target Harmful Subtypes

A new Aging-US review argues that senescent cells—often called 'zombie cells'—are not uniformly bad: some support tissue repair while others drive chronic inflammation and disease. This nuanced view is steering anti-aging research toward precision geroprotection, combining targeted therapies such as senolytics, senomorphics, and engineered immunotherapies to remove or modulate specific senescent cell subtypes. Advances rely on single-cell omics and related tools to map cell diversity across organs, but challenges remain, including identifying specific biomarkers, delivering treatments safely, and avoiding interference with beneficial tissue maintenance.

via SciTechDaily|

#aging #precision-geroprotection #science

science1 month ago•8 min saved

Cancer-fighting Strategy: Turning Iron-Heavy 'Zombie' Cells Against Their Tumors

Researchers uncovered a vulnerability in senescent “zombie” cells that accumulate in tumors and aging tissues: they rely on GPX4 to shield themselves from iron-driven ferroptosis. Blocking GPX4 with covalent inhibitors exposes these iron-loaded cells to ferroptotic death. In a screen of 10,000 compounds, four senolytics stood out, three targeting GPX4, and testing in three mouse cancer models showed reduced tumor size and improved survival, suggesting potential to combine this approach with chemotherapy or immunotherapy. Ongoing work will identify which cancers and patients are most likely to benefit and how this affects anti-tumor immunity.

via SciTechDaily|

#cancer-therapy #ferroptosis #gpx4

health3 years ago•4 min saved

"Strawberry Antioxidant and Hunger: Keys to Healthy Aging"

Longevity researcher Paul Robbins has been taking fisetin, a chemical compound found in strawberries, to help boost his immunity and reduce inflammation. Fisetin is a "senolytic" that targets and clears out "zombie" cells that build up in the body as people age. While there is no evidence in humans that fisetin has any benefit, Robbins is working to develop fisetin-based drugs that may work to clear these zombie cells from the body. However, experts caution against taking fisetin supplements until more research is done on its proper dosage and potential harms.

via Insider|

#anti-aging #fisetin #health

health3 years ago•2 min saved

Sam Altman and other tech leaders embrace anti-aging drugs.

Tech executives like Sam Altman are taking prescription pills like metformin and rapamycin to slow aging by taming "zombie cells" that can contribute to age-related diseases. Researchers are also working on repurposing existing drugs into new drug combinations called "senolytics" to flush some zombie cells out of the body. However, these drugs need more testing before they can be considered safe for everyone, and lifestyle interventions like exercise and dieting can also reduce senescent cell burden.

via Business Insider|

#anti-aging #health #metformin

health3 years ago•4 min saved

AI uncovers promising drug candidates for anti-aging and schizophrenia treatment.

Researchers from Integrated Biosciences have used artificial intelligence to identify three senolytic compounds that selectively kill aging-associated senescent cells, which have been implicated in a broad spectrum of age-related diseases and conditions including cancer, diabetes, cardiovascular disease, and Alzheimer's disease. The compounds discovered display high selectivity and favorable medicinal chemistry properties, making them more likely to succeed in clinical trials and eventually help restore health to aging individuals.

via Phys.org|

biomedical-research3 years ago•21 min saved

AI and Machine Learning Revolutionize Anti-Aging Drug Discovery.

Researchers have developed a deep neural network-based approach to identify small-molecule senolytics, drugs that selectively eliminate senescent cells, which contribute to aging and age-related diseases. The approach was able to identify several new senolytic compounds, which were validated in vitro and in vivo. The study demonstrates the potential of machine learning in drug discovery for aging and age-related diseases.

via Nature.com|

#aging #biomedical-research #deep-neural-networks

health3 years ago•4 min saved

Expert predicts first anti-aging pills available in 2028.

Pills that can help reverse the effects of aging could be on the market within five years, according to Andrew Steele, author of 'Ageless: The new science of getting older without getting old'. Steele points to existing medications, such as the diabetes tablet metformin, that could be retooled as anti-aging treatments in the 'very, very near term'. Steele believes that treatments we are likely to see in the near term will extend 'healthspan' by dealing with age-related diseases, delaying the onset of problems such as dementia.

via Daily Mail|

#aging #anti-aging-pills #biotech